Identification of anti-inflammatory diterpenes from the marine gorgonian Pseudopterogorgia elisabethae
Identification of anti-inflammatory diterpenes from the marine gorgonian Pseudopterogorgia elisabethae
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DOI：
10.1016/s0040-4020(03)00515-5
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发表时间：
2003-06-02
期刊：
影响因子：
2.1
通讯作者：
Jacobs, RS
中科院分区：
文献类型：
--
作者：
Ata, A;Kerr, RG;Jacobs, RS
通过对采自佛罗里达群岛的假柳珊瑚（Pseudopterogorgia elisabethae）萜类代谢产物的分析，鉴定出一种新的羟基醌类化合物，即elisabethadione（1），以及新的假蝶呤和开环假蝶呤。抗炎试验表明，elisabethadione比充分表征的假蝶呤A和E更有效。本报告还描述了共同出现的pseudopterosins和seco-pseudopterosins，二萜与amphilectane和serrulatane骨架，分别。这与我们先前描述的分离作为在P. elisabethae中唯一的二萜环化酶产物的elisabethatriene一起表明，二萜的两性内酯和锯齿内酯家族衍生自相同的香叶基香叶基二磷酸环化酶产物。(C)2003爱思唯尔科技有限公司版权所有。
Analysis of the terpene metabolites of Pseudopterogorgia elisabethae collected from the Florida Keys has resulted in the identification of a novel hydroxyquinone, elisabethadione (1), as well as new pseudopterosins and seco-pseudopterosins. Anti-inflammatory assays indicate that elisabethadione is more potent than the well characterized pseudopterosin A and E. This report also describes the co-occurrence of pseudopterosins and seco-pseudopterosins, diterpenes with amphilectane and serrulatane skeletons, respectively. This together with our previously described isolation of elisabethatriene as the sole diterpene cyclase product in P. elisabethae suggests that the amphilectane and serrulatane families of diterpenes are derived from the same geranylgeranyl diphosphate cyclase product. (C) 2003 Elsevier Science Ltd. All rights reserved.