Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
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DOI：
10.1016/j.neulet.2011.03.069
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发表时间：
2011-05
影响因子：
2.5
通讯作者：
Y. Yasuda;R. Hashimoto;K. Ohi;M. Fukumoto;S. Umeda‐Yano;H. Yamamori;T. Okochi;M. Iwase;H. Kazui;N. Iwata;M. Takeda
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文献类型：
--
作者：
Y. Yasuda;R. Hashimoto;K. Ohi;M. Fukumoto;S. Umeda‐Yano;H. Yamamori;T. Okochi;M. Iwase;H. Kazui;N. Iwata;M. Takeda
精神分裂症是一种遗传性很高的复杂疾病。患有精神分裂症的亲属不仅患精神分裂症的风险增加，而且患精神分裂症谱系障碍的风险也增加，如分裂型人格障碍。锌指蛋白804A(ZNF804A)基因的单核苷酸多态(SNP)rs1344706已被多项全基因组关联研究、后续关联研究和荟萃分析发现与精神分裂症的易感性有关。这种SNP已被证明影响神经元的连接性和认知能力。我们采用精神分裂症人格问卷(SPQ)对176名健康受试者进行了rs1344706基因ZNF804A与分裂型人格特征的相关性研究。我们还寻找ZNF804A基因多态性与SPQ评估的分裂类型的三个因素--认知/知觉、人际关系和组织障碍--之间的具体联系。T等位基因携带者的SPQ总分显著高于G/G等位基因携带者(P=0.042)。在SPQ得出的三个因子中，携带风险T等位基因的携带者表现出更高的组织紊乱因子(p=0.30)，但在认知/知觉或人际因素上，不同基因型组之间没有差异(p>；0.30)。这些结果表明，ZNF804A的遗传变异不仅可能增加精神分裂症的易感性，而且可能增加健康人分裂型人格特征的易感性。
Schizophrenia is a complex disorder with a high heritability. Relatives with schizophrenia have an increased risk not only for schizophrenia but also for schizophrenia spectrum disorders, such as schizotypal personality disorder. A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association studies, follow-up association studies and meta-analyses. This SNP has been shown to affect neuronal connectivities and cognitive abilities. We investigated an association between theZNF804Agenotype of rs1344706 and schizotypal personality traits using the Schizotypal Personality Questionnaire (SPQ) in 176 healthy subjects. We also looked for specific associations amongZNF804Apolymorphisms and the three factors of schizotypy—cognitive/perceptual, interpersonal and disorganization—assessed by the SPQ. The total score for the SPQ in carriers of the risk T allele was significantly higher than that in individuals with the G/G genotype (p= 0.042). For the three factors derived from the SPQ, carriers with the risk T allele showed a higher disorganization factor (p= 0.011), but there were no differences in the cognitive/perceptual or interpersonal factors between genotype groups (p> 0.30). These results suggest that the genetic variation inZNF804Amight increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects.