Near-neutrality in evolution of genes and gene regulation
Near-neutrality in evolution of genes and gene regulation
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DOI：
10.1073/pnas.252626899
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发表时间：
2002-12-10
影响因子：
11.1
通讯作者：
Ohta, T
中科院分区：
文献类型：
--
作者：
Ohta, T
近中性理论认为，漂移和选择的相互作用是重要的，并发生在不同的水平，包括同义和非同义的蛋白质编码区的取代和调控元件的序列转换。本文综述了该理论的最新进展，并指出在不同的水平上，漂移与选择之间的相互作用是不同的。弱选择力对同义变化的影响是稳定的，而对非同义变化的影响则取决于环境因素。调节元件分化的选择甚至比氨基酸变化更依赖于环境因素。特别重要的是漂移的作用，直接参与形态进化的基因调控的演变。接近中性的范围取决于受选定连锁基因座影响的群体的有效规模。除了有效群体大小，分子伴侣如热休克蛋白90对近中性范围有显著影响。
The nearly neutral theory contends that the interaction of drift and selection is important and occurs at various levels, including synonymous and nonsynonymous substitutions in protein coding regions and sequence turnover of regulatory elements. Recent progress of the theory is reviewed, and the interaction between drift and selection is suggested to differ at these different levels. Weak selective force on synonymous changes is stable, whereas its consequence on nonsynonymous changes depends on environmental factors. Selection on differentiation of regulatory elements is even more dependent on environmental factors than on amino acid changes. Of particular significance is the role of drift in the evolution of gene regulation that directly participates in morphological evolution. The range of near neutrality depends on the effective size of the population that is influenced by selected linked loci. In addition to the effective population size, molecular chaperones such as heat shock protein 90 have significant effects on the range of near neutrality.