Targeting tumor vasculature with homing peptides from phage display
Targeting tumor vasculature with homing peptides from phage display
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DOI：
10.1006/scbi.2000.0334
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发表时间：
2000-12-01
影响因子：
14.5
通讯作者：
Ruoslahti, E
中科院分区：
文献类型：
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作者：
Ruoslahti, E
肿瘤脉管系统以比正常组织的血管中所见的低得多的水平表达许多分子标志物，并且在某些情况下，这些标志物是不可检测的。这些标志物的存在与血管生成有关;经历血管生成的所有血管共享相同的标志物。血管生成血管中的内皮细胞、周细胞和平滑肌细胞以及血管细胞外基质可各自表达此类标记物。分子上，它们代表血管生长因子受体、细胞粘附、蛋白质及其受体。噬菌体展示库筛选的肽，家庭的肿瘤血管注射到小鼠后，最近提供了一个新的工具，用于分析肿瘤血管的区别特征。已经发现以这种方式分离的肿瘤归巢肽以及针对在肿瘤血管中表达的纤连蛋白形式的抗体用作靶向装置，以在体内模型中将药物和其他治疗材料集中到肿瘤。因此，这种靶向策略可以潜在地提高药物的功效并减少其副作用。
Tumor vasculature expresses a number of molecular markers at much lower levels than those seen in the blood vessels of normal tissues, and in some cases, such markers are undetectable. The presence of these markers relates to angiogenesis; the same markers are shared by all blood vessels undergoing angiogenesis. The endothelial cells, pericytes and smooth muscle cells, and the vascular extracellular matrix in angiogenic vessels can each express such markers. Molecularly, they represent vascular growth factor receptors, cell adhesion, proteins and their receptors. Screening of phage display libraries for peptides that home to tumor vasculature when injected into mice has recently provided a new tool for analyzing the distinguishing features of tumor vasculature. Tumor-homing peptides isolated in this manner, as well as an antibody against a form of fibronectin expressed in tumor blood vessels, have been found to serve as targeting devices to concentrate drugs and other therapeutic materials to tumors in in vivo models. Such a targeting strategy can therefore potentially improve the efficacy of drugs and reduce their side effects.