Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii
Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii
复制标题
DOI：
10.1016/j.bmcl.2010.01.051
复制
发表时间：
2010-03-15
影响因子：
2.7
通讯作者：
Morita, Hiroshi
中科院分区：
文献类型：
--
作者：
Hirasawa, Yusuke;Shoji, Tomokazu;Morita, Hiroshi
本文报道了一个新的双吲哚生物碱--双明党参碱A（bisleuconothine A）。根据2D NMR数据和X-射线衍射分析确定了其结构，包括绝对立体化学。Bisleuconothine A（1）对多种人癌细胞系显示细胞生长抑制活性。(C)2010爱思唯尔有限公司保留所有权利。
A new bisindole alkaloid, bisleuconothine A(1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A(1) showed cell growth inhibitory activity against various human cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved.