Screening and identification of haptoglobin showing its important role in pathophysiological process of gallbladder carcinoma
Screening and identification of haptoglobin showing its important role in pathophysiological process of gallbladder carcinoma
复制标题
触珠蛋白的筛选和鉴定显示其在胆囊癌病理生理过程中的重要作用
DOI：
10.1016/j.gene.2021.145429
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发表时间：
2021-02-01
期刊：
影响因子：
3.5
通讯作者：
Liang, Tingming
中科院分区：
文献类型：
--
作者：
Guo, Li;Liu, Mengting;Liang, Tingming
预后不良的胆囊癌（GBC）已成为世界范围内癌症相关死亡的主要原因。在这项研究中，我们旨在通过对多个数据集的综合分析和进一步的实验验证来筛选和鉴定GBC中的关键基因。我们首先筛选了一个候选的关键基因——上调触珠蛋白（upregulated haptoglobin， HP），进一步的分析和验证主要集中在HP的高富集水平是否与GBC的病理生理过程有关。HP在不同肿瘤类型中表达模式不同，其动态表达模式反映了其在不同组织和疾病阶段的时空特征，暗示了其在多种生物学过程中的作用。进一步实验验证，HP可促进GBC- sd细胞的增殖、迁移和侵袭，提示其参与GBC的病理生理过程。HP可能在GBC的发生发展中起着至关重要的作用，并有可能作为肿瘤预后和治疗的潜在生物标志物或靶点。
Gallbladder cancer (GBC) with poor prognosis has been a major cause of cancer-related deaths worldwide. In this study, we aimed to screen and identify crucial genes in GBC through integrative analysis of multiple datasets and further experimental validation. A candidate crucial gene, up-regulated haptoglobin (HP), was firstly screened, and then further analysis and validation mainly focused on whether higher enrichment level of HP was responsible for pathophysiological process of GBC. HP was found with diverse expression patterns in various cancer types, and the dynamic expression patterns indicated its spatiotemporal characteristics in different tissues and disease stages, implicating its role in multiple biological processes. Further experimental validation showed that HP could promote the GBC-SD cell proliferation, migration and invasion, implying its role in pathophysiological process of GBC. HP may have a crucial role in occurrence and development of GBC, and it provides possibility as a potential biomarker or target in cancer prognosis and treatment.