Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement
Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement
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DOI：
10.1111/j.1600-0625.2011.01321.x
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发表时间：
2011-09-01
影响因子：
3.6
通讯作者：
Hunzelmann, Nicolas
中科院分区：
文献类型：
--
作者：
Moinzadeh, Pia;Krieg, Thomas;Hunzelmann, Nicolas
背景资料：纤维化的特征在于由于细胞外基质蛋白的合成和降解之间的不平衡而导致结缔组织的过度积聚。系统性硬化症（SSc）是一种典型的慢性炎症性疾病，导致严重的皮肤和许多内脏器官的纤维化。问题解决：我们研究了血清MMP-7水平是否反映了系统性硬化症的纤维化反应的活性。实验设计：血清样本来自123例系统性硬化症患者。所有患者的MMP-血清水平与年龄匹配的健康controls.Results：显着增加中位血清MMP-7水平与SSc患者相比，与对照组。肺纤维化（LF）患者血清MMP-7水平中位数显著高于无肺纤维化患者。相应地，患者呼吸困难和DLCO（肺一氧化碳扩散能力）水平低于60%，表现出显着较高的中位数MMP-7 levels.Conclusions：MMP-7水平升高与SSc和LF的晚期。这些数据表明，在SSc MMP-7参与纤维化组织重塑的过程。
Background: Fibrosis is characterized by an excessive accumulation of connective tissue because of an imbalance between synthesis and I degradation of extracellular matrix proteins. Systemic sclerosis (SSc) is a prototypic chronic inflammatory disease leading to a severe fibrosis of the skin and many internal organs.Questions Addressed: We investigated whether serum MMP-7 levels reflect the activity of the fibrotic reaction in systemic sclerosis.Experimental Design: Serum samples were obtained from 123 patients with systemic sclerosis. MMP-serum levels of all patients with SSc were compared with age-matched healthy controls.Results: Significantly increased median serum MMP-7 levels were found in patients with SSc when compared with controls. The median MMP-7 serum level of patients with lung fibrosis (LF) was significantly higher compared with those without LE. Accordingly, patients with dyspnea and DLCO (diffusion capacity of the lung for carbon monoxide) levels below 60% showed significantly higher median MMP-7 levels.Conclusions: Elevated MMP-7 levels are associated with an advanced stage of SSc and LF. These data suggest that in SSc MMP-7 is involved in the process of fibrotic tissue remodelling.