Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints.
Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints.
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发表时间：
1988
影响因子：
5.6
通讯作者：
D. Tagle;B. Koop;M. Goodman;J. Slightom;D. Hess;R. Jones
中科院分区：
文献类型：
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作者：
D. Tagle;B. Koop;M. Goodman;J. Slightom;D. Hess;R. Jones
从胚胎，胎儿和成人获得的血液溶血产物中的珠蛋白组合物和高压液相色谱分析的序列分析的β和γ基因和编码的球蛋白和显示，原猴纲灵长类动物Galago crassicaudatus表达其β和γ基因只有胚胎。由于兔，小鼠和galago都有胚胎伽马基因，但猿类灵长类有胎儿伽马基因，我们得出结论，伽马E进化到伽马F在干猿。一个升高的非同义替换率的特点是这种过渡。对齐的γ和γ核苷酸序列和简约重建的进化历史，这些序列确定了几个古老的保守的顺式调控元件（系统发育足迹）的重要的γ表达在灵长类动物和顺式突变，可能已参与招聘的γ基因的胎儿程序在猿猴灵长类动物。
Sequence analysis of epsilon and gamma genes and encoded globins and high-pressure liquid chromatography analysis of globin compositions in blood hemolysates obtained from embryos, fetuses and adults show that the prosimian primate Galago crassicaudatus expresses its epsilon and gamma genes only embryonically. Since rabbit, mouse and galago all have embryonic gamma genes but simian primates have fetal gamma genes, we conclude that gamma E evolved into gamma F in stem-simians. An elevated non-synonymous substitution rate characterizes this transition. The alignment of epsilon and gamma nucleotide sequences and the parsimoniously reconstructed evolutionary history of these sequences identify several anciently conserved cis-regulatory elements (phylogenetic footprints) important for gamma expression in primates and also cis-mutations which may have been involved in the recruitment of the gamma gene to a fetal program in simian primates.