Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck.
Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck.
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DOI：
10.3390/ijms21186851
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发表时间：
2020-09-18
影响因子：
5.6
通讯作者：
Lin HP
中科院分区：
文献类型：
--
作者：
Su YW;Wu PS;Lin SH;Huang WY;Kuo YS;Lin HP
细胞能量代谢（例如脂质代谢）的重新编程是头颈鳞状细胞癌（SCCHN）的标志。然而，与脂肪酸氧化 (FAO) 相关的蛋白质表达是否影响 SCCHN 的存活仍不清楚。我们的目的是调查 SCCHN 患者中FAO相关酶的表达并确定其与临床病理变量的相关性。使用来自 102 个切除的 SCCHN 肿瘤的组织微阵列对FAO 相关蛋白表达（包括肉碱棕榈酰转移酶 1 (CPT1)、酰基辅酶 A 脱氢酶家族和脂肪酸合酶 (FAS)）进行免疫组织化学分析 (IHC)。根据 IHC 评分对表达进行分类，并确定与临床病理因素的统计关联。协变量调整后，长链酰基辅酶A脱氢酶（LCAD）的中等到高表达对癌症相关死亡具有保护作用（调整后的风险比（HR），0.2；95%置信区间（CI），0.05-0.87）。年龄和临床分期仍然是生存的独立预测因素（对于年龄，调整后的 HR，1.75；95% CI，1.22-2.49；对于 III/IV 期疾病，调整后的 HR，14.33；95% CI，1.89-108.60）。中链酰基辅酶A脱氢酶和FAS的过度表达与晚期肿瘤分期（T3/T4）相关；然而，这些因素都不是生存的独立预测因素。几种FAO相关酶上调，并且LCAD过度表达对晚期SCCHN患者的总生存期具有保护作用。 FAO 相关酶的表达可能对 SCCHN 的生存结果产生预后影响。
Reprogramming of cellular energy metabolism, such as lipid metabolism, is a hallmark of squamous cell carcinoma of the head and neck (SCCHN). However, whether protein expression related to fatty acid oxidation (FAO) affects survival in SCCHN remains unclear. We aimed to investigate FAO-related enzyme expression and determine its correlation with clinicopathological variables in SCCHN patients. Immunohistochemical analysis (IHC) of FAO-related protein expression, including carnitine palmitoyltransferase 1 (CPT1), the acyl-CoA dehydrogenase family, and fatty acid synthase (FAS), was performed using tissue microarrays from 102 resected SCCHN tumors. Expressions were categorized according to IHC scores, and the statistical association with clinicopathological factors was determined. Moderate-to-high expression of long-chain acyl-CoA dehydrogenase (LCAD) had a protective role against cancer-related death (adjusted hazard ratio (HR), 0.2; 95% confidence interval (CI), 0.05–0.87) after covariate adjustment. Age and clinical stage remained independent predictors of survival (adjusted HR, 1.75; 95% CI, 1.22–2.49 for age; adjusted HR, 14.33; 95% CI, 1.89–108.60 for stage III/IV disease). Overexpression of medium-chain acyl-CoA dehydrogenase and FAS correlated with advanced tumor stage (T3/T4); however, none of these factors were independent predictors of survival. Several FAO-related enzymes were upregulated and LCAD overexpression had a protective effect on overall survival in advanced SCCHN patients. FAO-related-enzyme expression might have a prognostic impact on survival outcomes in SCCHN.
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DOI：
10.1016/j.jpba.2010.07.040
发表时间：
2011-01-05
影响因子：
3.4
作者：
Chen, Zhihang;Liu, Ruorui;Cheng, Yuanguo
通讯作者：
Cheng, Yuanguo
DOI：
10.1016/j.biocel.2012.06.025
发表时间：
2012-11
影响因子：
4
作者：
Tripathi, Pratima;Kamarajan, Pachiyappan;Somashekar, Bagganahalli S.;MacKinnon, Neil;Chinnaiyan, Arul M.;Kapila, Yvonne L.;Rajendiran, Thekkelnaycke M.;Ramamoorthy, Ayyalusamy
通讯作者：
Ramamoorthy, Ayyalusamy
影响因子：
4.2
作者：
Houten, Sander Michel;Wanders, Ronald J. A.
通讯作者：
Wanders, Ronald J. A.
HIF-1 介导的酰基辅酶 A 脱氢酶和脂肪酸氧化抑制对于癌症进展至关重要
影响因子：
8.8
作者：
Huang, De;Li, Tingting;Zhang, Huafeng
通讯作者：
Zhang, Huafeng
影响因子：
6.2
作者：
Sandulache, Vlad C.;Ow, Thomas J.;Pickering, Curtis R.;Frederick, Mitchell J.;Zhou, Ge;Fokt, Izabela;Davis-Malesevich, Melinda;Priebe, Waldemar;Myers, Jeffrey N.
通讯作者：
Myers, Jeffrey N.