Evidence against the selfish operon theory
Evidence against the selfish operon theory
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DOI：
10.1016/j.tig.2004.04.001
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发表时间：
2004-06-01
影响因子：
11.4
通讯作者：
Hurst, LD
中科院分区：
文献类型：
--
作者：
Pál, C;Hurst, LD
根据自私操纵子假说，基因的聚类及其随后组织成操纵子对组成基因是有利的，因为它使弱选择、功能偶联的基因能够水平转移。其中大多数是非必需基因。从我们对大肠杆菌基因组的分析中，我们得出结论，自私操纵子假说不太可能提供聚类的一般解释，也不能解释操纵子的基因组成。与预期相反，具有相关功能的基本基因具有特别强的聚集倾向，即使它们不在操作子中。此外，必需基因在操纵子中尤其丰富。
According to the selfish operon hypothesis, the clustering of genes and their subsequent organization into operons is beneficial for the constituent genes because it enables the horizontal gene transfer of weakly selected, functionally coupled genes. The majority of these are expected to be non-essential genes. From our analysis of the Escherichia coli genome, we conclude that the selfish operon hypothesis is unlikely to provide a general explanation for clustering nor can it account for the gene composition of operons. Contrary to expectations, essential genes with related functions have an especially strong tendency to cluster, even if they are not in operons. Moreover, essential genes are particularly abundant in operons.