Cortical Activation Associated with Muscle Synergies of the Human Male Pelvic Floor
Cortical Activation Associated with Muscle Synergies of the Human Male Pelvic Floor
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DOI：
10.1523/jneurosci.2073-14.2014
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发表时间：
2014-10-08
影响因子：
5.3
通讯作者：
Kutch, Jason J.
中科院分区：
文献类型：
--
作者：
Asavasopon, Skulpan;Rana, Manku;Kutch, Jason J.
人类骨盆底肌肉已被证明与各种各样的肌肉协同工作，这已被认为是在功能任务期间对骨盆和骨盆稳定性的重要贡献者。然而，盆底肌肉协同作用的神经机制仍然未知。在这里，我们测试的假设，在运动皮层区域激活与盆底激活的神经基板的一部分，这种协同作用。我们首先使用肌电图记录扩展以前的研究结果，并表明，骨盆底肌肉激活协同臀肌的自愿激活过程中，但不是在手指肌肉的自愿激活。然后，我们表明，使用功能性磁共振成像（fMRI），中央前回的内侧壁的一个区域始终激活在自愿盆底肌肉激活和自愿臀肌激活，但不是在自愿手指激活。我们最终证实，使用经颅磁刺激，fMRI确定的内侧壁区域可能会产生盆底肌肉激活。因此，人类男性骨盆底的肌肉协同作用似乎涉及与骨盆底控制相关的运动皮质区的激活。
Human pelvic floor muscles have been shown to operate synergistically with a wide variety of muscles, which has been suggested to be an important contributor to continence and pelvic stability during functional tasks. However, the neural mechanism of pelvic floor muscle synergies remains unknown. Here, we test the hypothesis that activation in motor cortical regions associated with pelvic floor activation are part of the neural substrate for such synergies. We first use electromyographic recordings to extend previous findings and demonstrate that pelvic floor muscles activate synergistically during voluntary activation of gluteal muscles, but not during voluntary activation of finger muscles. We then show, using functional magnetic resonance imaging (fMRI), that a region of the medial wall of the precentral gyrus consistently activates during both voluntary pelvic floor muscle activation and voluntary gluteal activation, but not during voluntary finger activation. We finally confirm, using transcranial magnetic stimulation, that the fMRI-identified medial wall region is likely to generate pelvic floor muscle activation. Thus, muscle synergies of the human male pelvic floor appear to involve activation of motor cortical areas associated with pelvic floor control.