Somatosensorimotor function of the superior colliculus, somatosensory cortex, and lateral hypothalamus in the rat.
Somatosensorimotor function of the superior colliculus, somatosensory cortex, and lateral hypothalamus in the rat.
复制标题
大鼠上丘、体感皮层和外侧下丘脑的体感运动功能。
DOI：
10.1016/0014-4886(87)90307-4
复制
发表时间：
1987
影响因子：
5.3
通讯作者：
Schallert,T
中科院分区：
文献类型：
--
作者：
Barth,TM;Schallert,T
上丘在多模态感觉功能中的作用尚不明确，这在很大程度上是因为尚未明确区分体感效应和上丘深层损伤的姿势/运动效应。整个上丘的单侧病变损害了头部和眼睛对位于病变对侧身体一侧的触觉、视觉和听觉刺激的定向；然而，即使在没有感觉刺激的情况下，患有这种病变的动物也倾向于向左旋转，不能进行对侧头部运动。为了确定单侧上丘损伤是否会产生独立于头部运动/旋转偏差的体感觉不对称，采用了不需要侧头或躯干运动的神经学测试。在每个前肢上贴上小片胶背纸，记录接触和去除刺激的潜伏期。同时还进行了一系列标准的神经学测试。整个上丘被单侧切除，另外两组感觉运动皮层或外侧下丘脑受损。上丘病变在对侧定向和同侧旋转/姿势偏差方面产生预期的缺陷，但在头部运动无关的感觉运动测试中未能产生体感不对称。相比之下，感觉运动皮层和外侧下丘脑病变在头部运动无关的感觉运动测试中产生了严重的不对称性。我们得出结论，上丘参与控制头部外侧运动，其在体感觉功能中的作用与感觉运动皮层或下丘脑外侧区域的作用根本不同。
The role of the superior colliculus in multimodal sensory function is unsettled, in large part because a clear distinction between the somatosensory effects and the postural/motor effects of damage to the deep layers of the superior colliculus has not been obtained. Unilateral lesions of the entire superior colliculus impair orienting of the head and eyes to tactile, visual, and auditory stimuli presented on the side of the body contralateral to the lesion; however, even in the absence of sensory stimulation animals with such a lesion tend to circle ipsiversively and fail to make contralateral head movements. To determine whether or not unilateral damage to the superior colliculus produces a somatosensory asymmetry independently of head movement/circling biases, a neurological test was used in which lateral head or trunk movements were not required. Small pieces of adhesive-backed paper were attached to each forelimb and the latencies to contact and remove the stimuli were recorded. A battery of standard neurological tests was administered as well. The entire superior colliculus was removed unilaterally, and for comparison, the sensorimotor cortex or lateral hypothalamus were damaged in additional groups. Lesions of the superior colliculus produced the expected deficit in contralateral orienting and ipsilateral circling/postural biases, but failed to produce a somatosensory asymmetry in the head movement-independent sensorimotor test. In contrast, both sensorimotor cortex and lateral hypothalamus lesions produced a severe asymmetry in the head-movement-independent sensorimotor test. We conclude that the superior colliculus is involved in the control of lateral head movements and that its role in somatosensory function is fundamentally different from that of the sensorimotor cortex or lateral hypothalamus regions.