DSP variants may be associated with longitudinal change in quantitative emphysema
DSP variants may be associated with longitudinal change in quantitative emphysema
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DOI：
10.1186/s12931-019-1097-8
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发表时间：
2019-07-19
影响因子：
5.8
通讯作者：
Beaty, Terri H.
中科院分区：
文献类型：
--
作者：
Kim, Woori;Cho, Michael H.;Beaty, Terri H.
背景资料：以肺破坏为特征的肺气肿是慢性阻塞性肺疾病（COPD）的关键组成部分，并且与发病率和死亡率增加相关。全基因组关联研究（GWAS）已经确定了与定量肺气肿横断面测量相关的多种遗传因素，但肺气肿定量测量纵向变化的遗传决定因素仍在很大程度上未知。我们的研究旨在确定与纵向变化定量肺气肿相关的遗传变异测量的计算机断层扫描（CT）imaging.Methods：我们包括当前和前吸烟者从两个纵向队列：COPDGene，非西班牙裔白人（NHW）和非洲裔美国人（AA）的研究，并评估慢性阻塞性肺疾病纵向确定预测代理终点（ECLIPSE）。我们计算了基于胸部CT成像的肺气肿的两个定量指标的年度变化：低衰减面积百分比（
Background: Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS) have identified multiple genetic factors associated with cross-sectional measures of quantitative emphysema, but the genetic determinants of longitudinal change in quantitative measures of emphysema remain largely unknown. Our study aims to identify genetic variants associated with longitudinal change in quantitative emphysema measured by computed tomography (CT) imaging.Methods: We included current and ex-smokers from two longitudinal cohorts: COPDGene, a study of Non-Hispanic Whites (NHW) and African Americans (AA), and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). We calculated annual change in two quantitative measures of emphysema based on chest CT imaging: percent low attenuation area (