PREPARATION AND EVALUATION OF RADIOPAQUE HYDROGEL MICROSPHERES BASED ON PHEMA IOTHALAMIC ACID AND PHEMA IOPANOIC ACID AS PARTICULATE EMBOLI
PREPARATION AND EVALUATION OF RADIOPAQUE HYDROGEL MICROSPHERES BASED ON PHEMA IOTHALAMIC ACID AND PHEMA IOPANOIC ACID AS PARTICULATE EMBOLI
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DOI：
10.1002/jbm.820240803
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发表时间：
1990-08-01
期刊：
影响因子：
--
通讯作者：
MOHANTY, M
中科院分区：
文献类型：
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作者：
JAYAKRISHNAN, A;THANOO, BC;MOHANTY, M
高度多孔的聚（2-羟基乙基甲基丙烯酸酯）（PHEMA）微球，该微球通过在甲甲基甲基甲酯（甲基丙烯酸甲酯）（PMMA）和聚甲基乙烯（Tetrueene）和聚甲基乙二醇（Tetramethyleny gycclyene glyccol）（PTMCL）（PTMGOL）（PTMGOL）等聚合稀释剂（如聚合稀释剂）中，制备了2-羟基甲基丙烯酸酯（HEMA）的悬浮聚合聚合（HEMA）（HEMA） ）通过酯化酯化用艾丘脑酸和二甲酸的反应性羟基，两种放射性物质在临床上使用。在检查的各种溶剂和催化剂中，发现四氢呋喃（THF）和N''' - 二甲基寄生虫（DMPT）最适合获得高度转化率。超过30 wt％的碘可以与微球结合，这使得它们足够充分的放射线以在XoDAGROPTION上成像。碘化后，微球保持其孔隙率，肿胀能力，亲水性和表面形态。在大鼠中皮下的此类微球的初步植入研究在6个月内没有显示不良组织反应。建议这些微球被证明是在血管内栓塞中作为颗粒栓子的。
Highly porous poly(2-hydroxyethyl methacrylate) (PHEMA) microspheres prepared by suspension polymerization of 2-hydroxyethyl methacrylate (HEMA) in presence of polymeric diluents such as poly(methyl methacrylate) (PMMA) in toluene and poly(tetramethylene glycol) (PTMG) were made radiopaque by esterification of the reactive hydroxyl groups with iothalamic acid and iopanoic acid, two radiopaque substances clinically used. Of the various solvents and catalysts examined, tetrahydrofuran (THF) and N,N''-dimethyl paratoluidine (DMPT) were found to be best for obtaining a high degree of conversion. More than 30 wt% iodine could be bound to the microspheres which made them sufficiently radiopaque to be imaged radiographically. Microspheres retained their porosity, swelling ability, hydrophilicity, and surface morphology to a significant extent after iodination. Preliminary implantation studies of such microspheres subcutaneously in rats have shown no adverse tissue reactions over a 6-month period. It is suggested that these microspheres would prove to be useful as particulate emboli in endovascular embolization.