Quantitative measurement of biological substances in daily-life environment with the little-finger-size one-shot spectroscopic tomography
Quantitative measurement of biological substances in daily-life environment with the little-finger-size one-shot spectroscopic tomography
复制标题
小指大小一次性光谱断层扫描定量测量日常生活环境中的生物物质
DOI：
10.1117/12.2038836
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
I. Ishimaru
中科院分区：
文献类型：
--
作者：
Akane Ishida;Shun Sato;Sho Nakada;Satoru Suzuki;P. Abeygunawardhana;Kenji Wada;A. Nishiyama;I. Ishimaru
在日常生活环境中，迫切需要对人体皮肤中的生物物质进行定量测量，如血糖水平，以实现无创医疗器械。提出了具有高时间分辨率和强鲁棒性的小指尺度的傅里叶光谱层析成像方法。该方法是一种空间相移法近共程干涉仪。我们将传输型相对倾斜移相器安装在无限远校正光学系统的光学傅里叶变换平面上。移相器由长方体和楔形棱镜构成，以给出物镜光束各半通量之间的空间相对移相。在二维成像阵列器件上，从物镜表面上的每一个单亮点发出的干涉图以条纹图案的形式形成。由于所提出的方法是基于成像光学，因此只有焦平面发射的射线才能促进干涉图的形成。因此，测量平面可以被限制在焦平面上。从光谱层析成像中，仅在人体皮肤的局部血管区域，我们就可以获得精确的近红外光谱数据。根据相移量的大小，从多个强度数据中获得傅里叶光谱特征，从而提高了测定精度。从统计学的角度来看，检测器的分级是基于t分布，以样本数的平方根来改进的。为了保证测定的准确性，我们建立了统计模型，并论证了液体细胞葡萄糖传感器的可行性。
In daily-life environment, the quantitative measurement of biological substances, such as the blood glucose level in the human skin, is strongly required to realize the non-invasive healthcare apparatus. Fourier-spectroscopic-tomography of the little-finger-size with high time-resolution and with the strong robustness for mechanical vibrations is proposed. The proposed method is a kind of near-common-path interferometer with spatial phase-shift method. We install the transmission-type relative-inclined phase-shifter on the optical Fourier transform plane of the infinity corrected optical system. The phase shifter is constructed with the cuboid and wedge prisms to give the relative phase-shift spatially between each half-flux of the objective beams. The interferograms from each single-bright-point on an objective surface in a line are formed as fringe patterns on 2-dimensional imaging array devices. And because the proposed method is based on the imaging optics, only emitted rays from a focal plane can contribute forming of interferograms. Thus, the measurement plane can be limited onto the focal plane only. From the spectroscopic tomography, only at a localized vessel area in human skins, we can get the pinpointed near-infrared spectroscopic data. And we can expect the improvement of the determination precision, because a Fourier spectroscopic-character is acquired from multiple intensity data in accordance with amount of phase-shift. From the statistical point of view, the gradation of detector is improved with the square root of sample number, based on t-distribution. We constructed the statistical model to assure the determination accuracy, and demonstrated the feasibility of the glucose sensor using liquid cells.