Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense
Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense
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DOI：
10.1055/s-2005-873181
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发表时间：
2006-01-01
期刊：
影响因子：
2.7
通讯作者：
Kadota, S
中科院分区：
文献类型：
--
作者：
Nguyen, MTT;Awale, S;Kadota, S
从菊花的 MeCH 提取物中，分离出了一种新的黄酮葡萄糖苷，金合欢素 7-O-(3-O-乙酰基-β-D-吡喃葡萄糖苷) (1)，以及 27 种已知化合物，包括黄酮类、咖啡酰奎尼酸衍生物、酚类和单萜葡萄糖苷。它们的结构是根据光谱数据阐明的。化合物1-15、20-24和27以浓度依赖性方式显示出显着的黄嘌呤氧化酶抑制活性，并且化合物2-11和22显示出比阳性对照别嘌呤醇(IC50=2.50μM)更强的抑制活性，IC50值范围为0.13至2.31μM。动力学研究表明，1-15和20-24表现出类似别嘌呤醇的竞争型抑制作用，而27则表现出混合型抑制作用。
From the MeCH extract of the flowers of Chrysanthemum sinense, a new flavone glucoside, acacetin 7-O-(3-O-acetyl-beta-D-glucopyranoside) (1), has been isolated together with 27 known compounds including flavonoids, caffeoylquinic acid derivatives, phenolics, and a monoterpenoid glucoside. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 - 15, 20 - 24, and 27 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 2-11 and 22 showed more potent inhibitory activity, with IC50 values ranging from 0.13 to 2.31 mu M, than that of a positive control allopurinol (IC50 = 2.50 mu M). The kinetic study indicated that 1 - 15 and 20 - 24 displayed competitive-type inhibition like that of allopurinol, while 27 displayed a mixed-type inhibition.