HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS ASSOCIATED WITH VISCERAL LEISHMANIASIS: A Case Report
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS ASSOCIATED WITH VISCERAL LEISHMANIASIS: A Case Report
复制标题
与内脏利什曼病相关的噬血细胞淋巴组织细胞增多症：病例报告
DOI：
10.1080/08880010590964309
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发表时间：
2005
影响因子：
1.7
通讯作者：
N. Özbek
中科院分区：
文献类型：
--
作者：
E. Özyürek;F. Özçay;B. Yilmaz;N. Özbek
利什曼相关的噬血细胞淋巴组织细胞增多症是一种罕见的临床病理实体。这种情况通常很难诊断，所以治疗经常被推迟。本文报告一5岁男童，因发烧1个月、肝脾肿大及全血细胞减少而入院。血清检测显示转氨酶水平升高，高甘油三酯血症，高铁蛋白血症，纤维蛋白原水平正常。骨髓检查诊断为噬血细胞性淋巴组织细胞增多症。对病人进行了各种传染病的检测。除利什曼原虫外，其余均呈阴性，利什曼原虫是通过间接荧光抗体试验检测到的。两性霉素B治疗可在1周内显著缓解所有症状和体征。
Leishmania-associated hemophagocytic lymphohistiocytosis is a rare clinicopathological entity. This condition is often difficult to diagnose, so treatment is often delayed. This report describes the case of a 5-year-old boy who was admitted with fever of 1 month's duration, hepatosplenomegaly, and pancytopenia. Serum testing showed elevated transaminase levels, hypertriglyceridemia, hyperferritinemia, and normal fibrinogen level. Hemophagocytic lymphohistiocytosis was diagnosed on bone marrow examination. The patient was tested for various infectious agents. He was negative for all except Leishmania, which was detected by indirect fluorescent antibody testing. Treatment with amphotericin B resulted in a dramatic resolution of all signs and symptoms within 1 week.