Rapid Assembly of Diversely Functionalized Spiroindenes by a Three-Component Palladium-Catalyzed C-H Amination/Phenol Dearomatization Domino Reaction
Rapid Assembly of Diversely Functionalized Spiroindenes by a Three-Component Palladium-Catalyzed C-H Amination/Phenol Dearomatization Domino Reaction
复制标题
通过三组分钯催化的 C-H 胺化/苯酚脱芳构化多米诺反应快速组装不同功能化的螺茚
DOI：
10.1002/anie.201708310
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发表时间：
2017-11-06
影响因子：
16.6
通讯作者：
Luan, Xinjun
中科院分区：
文献类型：
--
作者：
Fan, Liangxin;Liu, Jingjing;Luan, Xinjun
在钯催化下，苯酚衍生的联芳化合物与N-苯甲酰氧基胺和降冰片二烯（NBD）的三组分反应被用于高度官能化的螺茚的组装。该多米诺过程是通过NBD辅助的C-H胺化反应和苯酚脱芳反应实现的，在一步中形成一个C-N键和两个C-C键。初步研究表明，这种转化的不对称控制是可行的手性配体。此外，一系列进一步的转化突出了这种方法的潜在综合效用。
A novel palladium-catalyzed three-component reaction of phenol-derived biaryls with N-benzoyloxyamines and norbornadiene (NBD) has been developed for the assembly of highly functionalized spiroindenes. This domino process was realized through NBD-assisted C-H amination and phenol dearomatization by forming one C-N bond and two C-C bonds in a single step. Preliminary studies indicated that asymmetric control of this transformation was feasible with chiral ligands. Moreover, the potential synthetic utility of this methodology was highlighted by a series of further transformations.