Honey increased saliva, plasma, and urine content of total nitrite concentrations in normal individuals
Honey increased saliva, plasma, and urine content of total nitrite concentrations in normal individuals
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DOI：
10.1089/1096620041938632
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发表时间：
2004-09-01
影响因子：
2.4
通讯作者：
Boni, NS
中科院分区：
文献类型：
--
作者：
Al-Waili, NS;Boni, NS
本研究探讨了口服蜂蜜溶液对唾液、血浆和尿液中总亚硝酸盐（一种稳定的一氧化氮代谢物）的影响。14名健康成人志愿者，年龄在25-50岁之间，9名男性和3名女性参加了这项研究。禁食14小时后测定唾液、血浆和尿液中的亚硝酸盐总量。然后要求每个受试者喝蜂蜜溶液（80克生蜂蜜溶解在250毫升水中）。在摄入蜂蜜溶液后1小时、2小时和3小时采集唾液和血液样本进行总亚硝酸盐测定，3小时后采集尿液样本进行总亚硝酸盐测定。空腹唾液中亚硝酸盐的平均总量为108 +/- 61.3 mumol/L，在1、2和3小时分别增加到130 +/- 62.9、131.2 +/- 59和135.1 +/- 64.3 mumol/L。饮蜂蜜前血浆总亚硝酸盐为22.41 +/- 16.22 mumol/L，饮蜂蜜后1、2、3 h分别增至34.71 +/- 18.13、29.38 +/- 14.29、33 +/- 13.09 mumol/L。饮用蜂蜜前尿总亚硝酸盐为75.8 +/- 54.79 mumol/L，摄入蜂蜜溶液3小时后增加到107.8 +/- 70.83 mumol/L。虽然统计上不显著，但蜂蜜溶液显示出增加人体不同生物体液（包括唾液、血浆和尿液）中总亚硝酸盐浓度的趋势。
This study investigated effects of oral honey solution on total nitrite, a stable nitric oxide metabolite, in saliva, plasma, and urine samples collected from normal subjects. Fourteen adult healthy volunteers, 25-50 years old, nine males and three females, were enrolled in the study. Total nitrite was estimated in saliva, plasma, and urine after 14 hours of food fasting. Each subject was then asked to drink honey solution (80 g of raw honey dissolved in 250 mL of water). Saliva and blood samples were collected at 1, 2, and 3 hours after ingestion of honey solution for total nitrite assay, while urine samples were collected after 3 hours for total nitrite assay. The mean total fasting nitrite in saliva was 108 +/- 61.3 mumol/L, which was increased to 130 +/- 62.9, 131.2 +/- 59, and 135.1 +/- 64.3 mumol/L at 1, 2, and 3 hours, respectively. Plasma total nitrite was 22.41 +/- 16.22 mumol/L before drinking honey, which was increased to 34.71 +/- 18.13, 29.38 +/- 14.29, and 33 +/- 13.09 mumol/L at 1, 2, and 3 hours, respectively, after drinking honey. Urine total nitrite before drinking honey was 75.8 +/- 54.79 mumol/L, which was increased to 107.8 +/- 70.83 mumol/L 3 hours after ingestion of honey solution. Although not statistically significant, honey solution showed a tendency to increase total nitrite concentration in different biological fluids from humans, including saliva, plasma, and urine.