Active and passive cigarette smoke and breast cancer survival
Active and passive cigarette smoke and breast cancer survival
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DOI：
10.1016/j.annepidem.2006.11.004
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发表时间：
2007-05-01
影响因子：
5.6
通讯作者：
Gammon, Marilie D.
中科院分区：
文献类型：
--
作者：
Sagiv, Sharon K.;Gaudet, Mia M.;Gammon, Marilie D.
目得：在一组浸润性乳腺癌病例中研究了乳腺癌诊断前主动和被动吸烟与生存率之间的关系（n = 1273）参与一项基于人群的病例对照研究。参与者在1996年8月1日至1997年7月31日期间被诊断患有第一原发性乳腺癌，随访至2002年12月31日，全因死亡率结果：在考克斯模型中，与从不吸烟者相比，当前和既往吸烟者的全因死亡率的校正风险比（HR）略高（HR，1.23; 95%置信区间[95% CI]，0.83-1.84）和1.19（95% CI，0.85-1.66））。主动吸烟或被动吸烟与乳腺癌特异性死亡率之间没有关联。绝经后的主动吸烟者的全因死亡率和乳腺癌特异性死亡率较高（HR，1.64; 95% CI，1.03-2.60和HR，1.45; 95% CI，0.78-2.70）或诊断时肥胖（HR，2.10; 95% CI，1.03-4.27和HR，1.97; 95% CI，0.89-4.36）。吸烟和全因和乳腺癌特异性死亡率之间的关联并没有通过癌症treatment.CONCLUSIONS：这些数据并没有提供强有力的证据吸烟和全因或乳腺癌特异性死亡率之间的关联，虽然吸烟者绝经后或肥胖的诊断可能是在更高的风险。《流行病学年鉴》2007;17：385-393。(C)2007爱思唯尔公司All rights reserved.
PURPOSE: The association between active and passive cigarette smoking before breast cancer diagnosis and survival was investigated among a cohort of invasive breast cancer cases (n = 1273) participating in a population-based case-control study.METHODS: Participants diagnosed with a first primary breast cancer between August 1, 1996, and July 31, 1997, were followed-up until December 31, 2002, for all-cause mortality (n = 188 deaths), including breast cancer-specific mortality (n = 111), as reported to the National Death Index.RESULTS: In Cox models, the adjusted hazards ratios (HRs) for all-cause mortality were slightly higher among current and former active smokers, compared with never smokers (HR, 1.23; 95% confidence interval [95% CI], 0.83-1.84) and 1.19 (95% CI, 0.85-1.66), respectively). No association was found between active or passive smoking and breast cancer-specific mortality. All-cause and breast cancer-specific mortality was higher among active smokers who were postmenopausal (HR, 1.64; 95% CI, 1.03-2.60 and HR, 1.45; 95% CI, 0.78-2.70, respectively) or obese at diagnosis (HR, 2.10; 95% CI, 1.03-4.27 and HR, 1.97; 95% CI, 0.89-4.36, respectively). Associations between smoking and all-cause and breast cancer-specific mortality did not differ by cancer treatment.CONCLUSIONS: These data do not provide strong evidence for an association between smoking and all, cause or breast cancer-specific mortality, although smokers who are postmenopausal or obese at diagnosis may be at higher risk. Ann Epidemiol 2007;17:385-393. (C) 2007 Elsevier Inc. All rights reserved.