Phase inversion dynamics of PLGA solutions related to drug delivery
Phase inversion dynamics of PLGA solutions related to drug delivery
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DOI：
10.1016/s0168-3659(98)00158-8
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发表时间：
1999-03-29
影响因子：
10.8
通讯作者：
McHugh, AJ
中科院分区：
文献类型：
--
作者：
Graham, PD;Brodbeck, KJ;McHugh, AJ
暗底光学显微镜、电子显微镜和高效液相色谱 (HPLC) 已用于量化配方变化对基于 PLGA 的药物递送系统的相转化动力学和体外药物释放特性的影响。凝胶生长速率和水流入速率由相应前运动随时间的平方图确定。结果表明，在恒定形态下加速溶液凝胶速率的添加剂会导致较高的初始释放速率。相反，减缓凝胶化速率的添加剂会显着降低初始药物释放速率并导致更致密的海绵状形态。此外，无论溶液是用水、PBS缓冲溶液还是马血清淬灭，相转化动力学和形态都是相同的。 (C) 1999 Elsevier Science B.V. 保留所有权利。
Dark ground optical microscopy, electron microscopy, and high performance liquid chromatography (HPLC) have been used to quantify the effects of formulation changes on the phase inversion dynamics and in vitro drug release properties of a PLGA-based drug delivery system. Gel growth rates and water influx rates are determined from plots of the square of the respective front motion with time. Results show that additives that accelerate the solution gelation rate at constant morphology result in high initial release rates. Conversely, additives that slow the rate of gelation dramatically reduce the initial drug release rate and lead to a more dense sponge-like morphology. Moreover, the phase inversion dynamics and morphology are the same regardless of whether the solutions are quenched with water, a PBS buffer solution or horse serum. (C) 1999 Elsevier Science B.V. All rights reserved.