Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione.
Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione.
复制标题
脑室内给予色胺-4,5-二酮后大鼠大脑的神经化学变化。
DOI：
10.1016/0028-3908(92)90170-t
复制
发表时间：
1992
影响因子：
4.7
通讯作者：
Volicer,L
中科院分区：
文献类型：
--
作者：
Chen,JC;Schnepper,PW;To,A;Volicer,L
将血清素（5-HT）的神经毒性衍生物色胺-4,5-二酮（4,5- dkt）注射到大鼠侧脑室，以评价其生化作用。4,5-DKT治疗后3、7、14天分别检测海马、纹状体和前额叶皮层中8种物质的含量。5-羟色胺和5-羟基吲哚乙酸（5-HIAA）水平在第7天和第14天分别下降。在被检查的三个大脑区域中，色胺-4,5-二酮对多巴胺能系统或肾上腺素能系统或色氨酸和酪氨酸水平没有显著影响。在给予4,5- dkt后14天，观察到皮层色氨酸羟化酶活性降低。然而，给药4,5- dkt并没有改变[3H]帕罗西汀与神经末梢的结合，[3H]帕罗西汀是一种摄取5-HT的特异性拮抗剂。这些结果表明，4,5- dkt产生5-HT的消耗，但不消除5-羟色胺能神经末梢。
Tryptamine-4,5-dione (4,5-DKT) a neurotoxic derivative of serotonin (5-HT), was injected into the lateral ventricle of the rat in order to evaluate its biochemical effects. The levels of 8 substances in the hippocampus, striatum and prefrontal cortex were examined 3, 7 and 14 days after treatment with 4,5-DKT. 5-Hydroxytryptamine and 5-hydroxyindoleacetic acid (5-HIAA) levels were decreased in all three regions by days 7 and 14, respectively. Tryptamine-4,5-dione had no significant effect on dopaminergic or adrenergic systems or on the levels ofl-tryptophan andl-tyrosine, in any of the three areas of brain examined. Reduced activity of tryptophan hydroxylase in the cortex was observed 14 days after administration of 4,5-DKT. However, administration of 4,5-DKT did not alter the binding of [3H]paroxetine, a specific antagonist of the uptake of 5-HT, to nerve terminals. These results indicate that 4,5-DKT produced depletion of 5-HT without eliminating serotoninergic nerve terminals.