Polymer microcapsules with carbohydrate-sensitive properties
Polymer microcapsules with carbohydrate-sensitive properties
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DOI：
10.1002/adfm.200701291
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发表时间：
2008-05-23
影响因子：
19
通讯作者：
Sukhorukov, Gleb B.
中科院分区：
文献类型：
--
作者：
Levy, Tatjana;Dejugnat, Christophe;Sukhorukov, Gleb B.
碳水化合物敏感性聚合物多层膜通过多糖甘露聚糖和接枝到聚丙烯酸（PAA）上的苯基硼酸部分之间可逆的共价酯形成而组装到平坦基底和胶体CaCO 3颗粒上。所得多层膜对几种碳水化合物敏感，并且对果糖显示出最高的敏感性。对碳水化合物的响应产生于小分子量糖和甘露聚糖与膜内的硼酸基团的竞争性结合，并且被观察为在与高于临界浓度的含糖溶液接触时多层膜的快速溶解。此外，碳水化合物敏感的多层胶囊的制备，和糖依赖性的稳定性进行了研究，通过以下的释放包封的四甲基罗丹明异硫氰酸酯-牛血清白蛋白（TRITC-BSA）。
Carbohydrate-sensitive polymer multilayers are assembled onto flat substrates and colloidal CaCO3 particles via reversible covalent ester formation between the polysaccharide mannan and phenylboronic acid moieties grafted onto poly(acrylic acid) (PAA). The resulting multilayer films are sensitive to several carbohydrates, and show the highest sensitivity to fructose. The response to carbohydrates arises from the competitive binding of small molecular weight sugars and mannan to boronic acid groups within the films, and is observed as a rapid dissolution of the multilayers upon contact with a sugar-containing solution above a critical concentration. In addition, carbohydrate-sensitive multilayer capsules are prepared, and their sugar-dependent stability is investigated by following the release of encapsulated tetramethylrhodamine isothiocyanate-bovine serum albumin (TRITC-BSA).