Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.
Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.
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人滑膜细胞：前列腺素和 1-肾上腺素的激活和脱敏。
DOI：
10.1073/pnas.72.8.3124
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发表时间：
1975
影响因子：
11.1
通讯作者：
J. Fahey
中科院分区：
文献类型：
--
作者：
D. Newcombe;C. Ciosek;Y. Ishikawa;J. Fahey
人滑膜细胞在与前列腺素E1、前列腺素E2或l-肾上腺素孵育后，其细胞内腺苷3 '：5'-环磷酸（cAMP）浓度显著增加。细胞可以对这些激素脱敏。激素诱导的脱敏是受体位点特异性的，并与细胞内3 '：5'-环AMP磷酸二酯酶（EC 3.1.4. 17; 3 '：5'-环AMP 5 '-核苷酸水解酶）活性，而cAMP诱导的脱敏不是激素特异性的。
The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.