Association between obesity and a prothrombotic state: the Framingham Offspring Study
Association between obesity and a prothrombotic state: the Framingham Offspring Study
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DOI：
10.1160/th03-01-0014
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发表时间：
2004-04-01
影响因子：
6.7
通讯作者：
Tofler, GH
中科院分区：
文献类型：
--
作者：
Rosito, GA;D'Agostino, RB;Tofler, GH
尽管肥胖与心血管风险增加有关，但其机制尚未得到充分解释。由于血栓形成是心血管疾病的重要组成部分，因此我们研究了肥胖与止血因素之间的关系。我们在弗雷明汉后代研究的第 5 周期中研究了 3230 名没有心血管疾病史的受试者（55% 为女性，平均年龄 54 岁）。肥胖是通过体重指数和腰臀比来评估的。采集空腹血样，检测纤维蛋白原、纤溶酶原激活物抑制剂（PAI-I）抗原、组织纤溶酶原激活物（tPA）抗原、VII因子抗原、血管性血友病因子（VWF）和血浆粘度。男性和女性的体重指数均与纤维蛋白原、因子 VII、PAI-I 和 tPA 抗原直接相关 (p
Although obesity is associated with increased cardiovascular risk, the mechanism has not been fully explained. Since thrombosis is a critical component of cardiovascular disease, we examined the relationship between obesity and hemostatic factors. We studied 3230 subjects (55% females, mean age 54 years) without a history of cardiovascular disease in cycle 5 of the Framingham Offspring Study. Obesity was assessed by body mass index and waist-to-hip ratio. Fasting blood samples were obtained for fibrinogen, plasminogen activator inhibitor (PAI-I) antigen, tissue plasminogen activator (tPA) antigen, factor VII antigen, von Willebrand factor (VWF), and plasma viscosity. Body mass index was directly associated with fibrinogen, factor VII, PAI-I and tPA antigen in both men and women (p