The use of photon absorptiometry in the diagnosis of renal osteodystrophy.
The use of photon absorptiometry in the diagnosis of renal osteodystrophy.
复制标题
光子吸收测定法在肾性骨营养不良诊断中的应用。
作者：
H. Griffiths;R. Zimmerman;G. Bailey;R. Snider
通过使用 125I 准直点源测量骨矿物质，对 303 名肾衰竭患者的下臂皮质骨进行了 700 次测量，代表了该疾病的各个阶段。在这些患者中，123 人接受了移植手术。可以得出以下结论： (a) 长期氮质血症会导致骨矿物质严重流失，而在早期阶段，只能使用光子吸收测定法检测到骨矿物质流失。 (b) 透析期间骨矿物质逐渐流失，(c) 甲状旁腺切除术可减缓这种流失，但无法逆转。 (d) 移植后，骨质流失的速度会降低或停止，但很少有患者表现出骨矿物质的增加。 (e) 这些患者的初步生化数据显示骨矿物质与肌酐、血清磷酸盐和血清钙值之间的关系。
By using a 125I collimated point source to measure bone mineral, 700 measurements were obtained from the cortical bone of the lower arm in 303 patients with renal failure representing every stage of the disease. Of these patients, 123 had received transplants. The following conclusions can be drawn: (a) Prolonged azotemia leads to severe loss of bone mineral, which, in early stages, is only detectable using photon absorptiometry. (b) Gradual loss of bone mineral occurs during dialysis, (c) Parathyroidectomy slows this loss but fails to reverse it. (d) After transplantation, the rate of bone loss will either decrease or cease, but few patients show any increase in bone mineral. (e) Preliminary biochemical data on these patients show a relationship between bone mineral and creatinine, serum phosphate and serum calcium values.