Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix.
Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix.
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DOI：
10.1021/acsmacrolett.6b00702
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发表时间：
2016-10
影响因子：
5.8
通讯作者：
Teng Su;Yi Liu;Hongjian He;Jia Li;Yanan Lv;Lili Zhang;Yao Sun;C. Hu
中科院分区：
文献类型：
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作者：
Teng Su;Yi Liu;Hongjian He;Jia Li;Yanan Lv;Lili Zhang;Yao Sun;C. Hu
受透明关节软骨的精致架构的启发，我们报告了一种仿生聚合物水凝胶，其结合了强的分子间氢键，包括氨基甲酸酯-氨基甲酸酯键和氨基甲酸酯-酯键。所得水凝胶的含水量约为75%，可以承受高达56 MPa的压缩应力和98%的应变，并表现出可调的压缩模量（0.19-1.38 MPa），以及韧性（3629-28290 J m-2）在很宽的范围内。拉伸强度和弹性模量分别高达0.56和5.5MPa。高刚度和韧性使凝胶能够承受循环压缩载荷而不破裂。此外，我们的水凝胶模拟软骨和骨组织的细胞外基质，并提供支持软骨细胞的三维增殖和前成骨细胞的成骨分化的生化和物理线索。
Inspired by the delicate architecture of hyaline articular cartilage, we report on a biomimetic polymer hydrogel that incorporates strong intermolecular hydrogen bonding between urethane-urethane linkages as well as urethane-ester linkages. The resultant hydrogel, containing ≈75% water, can endure a compressive stress up to 56 MPa with a strain of 98%, and exhibit tunable compressive modulus (0.19-1.38 MPa), as well as toughness (3629-28290 J m-2) within a wide range. The tensile strength and elastic modulus reach as high as 0.56 and 5.5 MPa, respectively. The high stiffness and toughness enable the gel to withstand cyclic compressive loadings without fracturing. Moreover, our hydrogel mimics the extracellular matrices of cartilage and bone tissues and provides biochemical and physical cues that support the three-dimensional proliferation of chondrocytes and osteogenic differentiation of preosteoblasts.