THERMODYNAMICS OF THE DISPROPORTIONATION OF ADENOSINE 5'-DIPHOSPHATE TO ADENOSINE 5'-TRIPHOSPHATE AND ADENOSINE 5'-MONOPHOSPHATE .1. EQUILIBRIUM-MODEL
THERMODYNAMICS OF THE DISPROPORTIONATION OF ADENOSINE 5'-DIPHOSPHATE TO ADENOSINE 5'-TRIPHOSPHATE AND ADENOSINE 5'-MONOPHOSPHATE .1. EQUILIBRIUM-MODEL
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DOI：
10.1016/0301-4622(91)80024-l
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发表时间：
1991-07-01
影响因子：
3.8
通讯作者：
TEWARI, YB
中科院分区：
文献类型：
--
作者：
GOLDBERG, RN;TEWARI, YB
本文讨论了5 '-二磷酸腺苷与5'-三磷酸腺苷和5 '-单磷酸腺苷的缩合反应的热力学处理。该反应的平衡模型考虑了离子和金属结合物种的多样性以及长程静电和短程排斥作用的影响。计算的量包括平衡常数、比热、热容、熵和整个反应的化学计量。如何这些计算可以作出自洽相对于两个计算值的游离镁离子的离子强度和质量摩尔浓度的问题进行了讨论。涉及质子和镁离子结合的数据，在此反应中所涉及的核苷酸的热力学数据进行了评价。
The thermodynamic treatment of the disproportionation reaction of adenosine 5'-diphosphate to adenosine 5'-triphosphate and adenosine 5'-monophosphate is discussed in terms of an equilibrium model which includes the effects of the multiplicity of ionic and metal bound species and the presence of long range electrostatic and short range repulsive interactions. Calculated quantities include equilibrium constants, enthalpies, heat capacities, entropies, and the stoichiometry of the overall reaction. The matter of how these calculations can be made self-consistent with respect to both calculated values of the ionic strength and the molality of the free magnesium ion is discussed. The thermodynamic data involving proton and magnesium-ion binding data for the nucleotides involved in this reaction have been evaluated.