Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children's Health.
Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children's Health.
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DOI：
10.3390/ijerph15010120
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发表时间：
2018-01-11
影响因子：
--
通讯作者：
Kishi R
中科院分区：
文献类型：
--
作者：
Minatoya M;Itoh S;Araki A;Tamura N;Yamazaki K;Miyashita C;Kishi R
Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06–0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age.
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影响因子：
2.4
作者：
Jiang, Nona M.;Tofail, Fahmida;Petri, William A., Jr.
通讯作者：
Petri, William A., Jr.
影响因子：
8
作者：
Hassink, SG;deLancey, E;Funanage, VL
通讯作者：
Funanage, VL
影响因子：
4.7
作者：
Kishi R;Araki A;Minatoya M;Hanaoka T;Miyashita C;Itoh S;Kobayashi S;Ait Bamai Y;Yamazaki K;Miura R;Tamura N;Ito K;Goudarzi H;members of The Hokkaido Study on Environment and Children’s Health
通讯作者：
members of The Hokkaido Study on Environment and Children’s Health
影响因子：
5.2
作者：
Kwon H;Pessin JE
通讯作者：
Pessin JE
影响因子：
8
作者：
Delobel-Ayoub, Malika;Kaminski, Monique;Larroque, Beatrice
通讯作者：
Larroque, Beatrice