In vivo monitoring of intravenously injected gold nanorods using near-infrared light
In vivo monitoring of intravenously injected gold nanorods using near-infrared light
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DOI：
10.1002/smll.200700438
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发表时间：
2008-07-01
期刊：
影响因子：
13.3
通讯作者：
Niidome, Yasuro
中科院分区：
文献类型：
--
作者：
Niidome, Takuro;Akiyama, Yasuyuki;Niidome, Yasuro
金纳米棒在近红外区域显示表面等离子体（SP）带，被用作生物成像探针，在小鼠中响应近红外光。通过使用配备有积分球的分光光度计从小鼠腹部直接监测静脉注射的聚乙二醇修饰的金纳米棒的SP带。金纳米棒在900 nm处的吸光度在注射后立即增加并达到稳定状态。注射磷脂酰胆碱修饰的金纳米棒也增加了900 nm处的吸光度，但吸光度以1.3分钟的半衰期呈指数下降。金纳米棒在体内的光谱变化依赖于其表面特性，并且可以使用简单的光谱测量在真实的时间内观察到。
Gold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene glycol-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend-on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.