Prediction of CD4 count from CD4 percentage: experience from three laboratories.
Prediction of CD4 count from CD4 percentage: experience from three laboratories.
复制标题
从 CD4 百分比预测 CD4 计数：来自三个实验室的经验。
DOI：
10.1097/00002030-199307000-00005
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Gelman,R
中科院分区：
文献类型：
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作者：
Kidd,PG;Cheng,SC;Paxton,H;Landay,A;Gelman,R
目的：CD 4计数已被用于监测HIV感染的疾病进展，作为开始治疗的标准，并在临床试验中对患者进行分层和随访。最近，疾病控制和预防中心（CDC）已将CD 4计数作为HIV疾病分类的一部分。由于CD 4百分比可能是唯一可用的实验室信息，因此启动本研究以确定CD 4百分比和CD 4计数之间的相关性是否足够高，以使这些测量值能够相互替代。来自华盛顿大学（UW）的1000次连续CD 4测量用于创建模型，该模型使用来自马里兰州医学实验室（MML）和拉什-长老会-圣卢克医学中心（Rush）的1000个CD 4测量值的数据集进行测试。这些患者未根据年龄、性别、风险组或治疗进行选择。已知来自MML和Rush的所有患者均为HIV阳性，而所有UW患者的HIV状态未知。结果：该模型预测CD 4百分比>. 14%的人CD 4计数>= 200 X 109/l（如果使用149%的CD 4百分比，则9%的患者的CD 4计数>= 200 X 10%），并且CD 4百分比= 27%的患者的CD 4计数>= 500 X 10%（如果使用27%的CD 4百分比，则17%的患者的CD 4计数> 500 × 109/l）。
Objective: CD4 counts have been used to monitor progression of disease in HIV infection as criteria for initiation of therapy, and to stratify and follow patients in clinical trials. Recently, the Centers for Disease Control and Prevention (CDC) has made CD4 counts part of the classification of HIV disease. Because a CD4 percentage may be the only laboratory information available, this study was initiated to determine whether the correlation between CD4 percentages and CD4 counts is sufficiently high to enable these measures to be substituted for each other.Design, setting and patients: One thousand consecutive CD4 measurements from the University of Washington (UW) were used to create a model that was tested using datasets of 1000 CD4 measurements each from Maryland Medical Laboratories (MML) and Rush-Presbyterian-St Luke's Medical Center (Rush). Ihe patients were not selected for age, sex, risk group or treatment. All patients from MML and Rush were known to be HlV-positive, while the HlV status of all UW patients was unknown. Results: The model predicted that a patient with a CD4 percentage>. 14% would have a CD4 count>= 200 X 109/l (if CD4 percentage of 149% was used, 9% of patients would have a CD4 count>= 200 X 10%), and a patient with a CD4 percentage= 27% would have a CD4 count>= 500 X 10%(if CD4 percentage of 27% was used, 17% of patients would have a CD4 count> 500 X 109/l).