CHEMOTHERAPEUTIC CONTROL TRIAL OF PLASMODIUM FALCIPARUM WITH A COMBINATION OF CHLOROQUINE AND PRIMAQUINE ON SELECTIVE AGE GROUP IN A COASTAL VILLAGE OF NORTH SUMATRA, INDONESIA
CHEMOTHERAPEUTIC CONTROL TRIAL OF PLASMODIUM FALCIPARUM WITH A COMBINATION OF CHLOROQUINE AND PRIMAQUINE ON SELECTIVE AGE GROUP IN A COASTAL VILLAGE OF NORTH SUMATRA, INDONESIA
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印度尼西亚北苏门答腊岛沿海村庄的特定年龄组使用氯喹和伯氨喹联合治疗恶性疟原虫的化疗控制试验
DOI：
10.2149/tmh1973.15.257
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
W. Panjaitan
中科院分区：
文献类型：
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作者：
H. Matsuoka;A. Ishii;W. Panjaitan
1983年9月至1984年7月，在印度尼西亚北苏门答腊岛的一个沿海村庄，为控制疟疾，对15岁以下的选定年龄组的儿童进行了疟疾主动病例检测和治疗。氯喹与伯氨喹联合使用3天或5天比氯喹单独使用3天更有效。该活性降低了脾脏率、恶性疟原虫的寄生率、恶性疟原虫的寄生公式和寄生虫密度指数。1984年7月（1980-1983年），在无病媒控制活动的情况下，恶性疟原虫的寄生率和寄生配方均未上升（分别为12.3%和14.3%），但每年7- 9月（1980-1983年），恶性疟原虫的寄生率和寄生配方均上升了27-61%，恶性疟原虫的寄生配方均上升了50-86%。1984年7月的大多数病人被认为是间日疟原虫复发或治疗不当的病例。学龄前儿童恶性疟原虫配子细胞密度高于学龄儿童。我们应该特别关注学龄前儿童，以阻断针对配子体阶段的疟疾传播。同时检测葡萄糖-6-磷酸脱氢酶（G6PD）缺乏，G6PD缺乏的疟疾患者不给予伯氨喹。
Active case detection and treatment of malaria in a selective age group of children up to the age of fifteen was carried out to control malaria in a coastal village in North Sumatra, Indonesia from September 1983 to July 1984. A combination of chloroquine for three days with primaquine for three or five days was more effective than only chloroquine for three days. The spleen rate, the parasite rate of P. falciparum, the parasite formula of P. falciparum and the parasite density index were reduced by this activity. The parasite rate and the parasite formula of P. falciparum did not rise up in July 1984 (12.3% and 14.3%, respectively) without any vector control activities, although the parasite rate used to rise up to 27-61% and the parasite formula of P. falciparum was 50-86% in July to September every year (1980-1983). Most of the patients in July 1984 were considered to be recurrent or inadequately treated cases of P. vivax. Furthermore the density of P. falciparum gametocyte in pre-school children was higher than that in school children. We should pay a special attention to pre-school children to interrupt malaria transmission aiming at the gametocyte stage. Detection of glucose-6-phosphate dehydrogenase (G6PD) deficiency was done at the same time and malaria patient with G6PD deficiency was not given primaquine.