The Mediator complex: a master coordinator of transcription and cell lineage development
The Mediator complex: a master coordinator of transcription and cell lineage development
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介导复合体：转录和细胞谱系发育的主协调者
DOI：
10.1242/dev.098392
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发表时间：
2014-03-01
期刊：
影响因子：
4.6
通讯作者：
Wang, Gang
中科院分区：
文献类型：
--
作者：
Yin, Jing-wen;Wang, Gang
介体是RNA聚合酶II进行基因转录所需的多蛋白复合物。复合物的多个亚基在将来自信号和转录因子的信息传递到RNA聚合酶II机制中显示出特异性，从而能够控制特定基因的表达。最近的研究也提供了新的机制的见解介导的作用，表观遗传调控，转录延伸，终止，mRNA加工，非编码RNA激活和超级增强子的形成。基于这些在基因调控中的特定作用，Mediator已成为发育和细胞谱系确定的主要协调者。在这里，我们描述了最新的进展，了解中介功能的机制，强调其在发展和疾病中的作用。
Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase II. Multiple subunits of the complex show specificity in relaying information from signals and transcription factors to the RNA polymerase II machinery, thus enabling control of the expression of specific genes. Recent studies have also provided novel mechanistic insights into the roles of Mediator in epigenetic regulation, transcriptional elongation, termination, mRNA processing, noncoding RNA activation and super enhancer formation. Based on these specific roles in gene regulation, Mediator has emerged as a master coordinator of development and cell lineage determination. Here, we describe the most recent advances in understanding the mechanisms of Mediator function, with an emphasis on its role during development and disease.