THE BASICITIES OF SUBSTITUTED PYRIDINES AND THEIR 1-OXIDES
THE BASICITIES OF SUBSTITUTED PYRIDINES AND THEIR 1-OXIDES
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DOI：
10.1021/ja01622a001
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发表时间：
1955-01-01
影响因子：
15
通讯作者：
DOAK, GO
中科院分区：
文献类型：
--
作者：
JAFFE, HH;DOAK, GO
最近有人提出，苯中的^; CH基团被杂原子如^ N 2或被取代的杂原子如-O 3取代的效果可以用Hammett方程表示，4并且已经提出了这两个基团的取代基常数。本文讨论了上述过程是否可以逆转的问题，即Hammett方程是否可以用来预测杂环芳香族化合物中取代基对杂原子或杂原子侧链反应性的影响。遗憾的是，关于简单单取代单环杂环化合物的反应性的实验数据很少报道。
It has recently been suggested that the effect of replacing a^; CH group in benzene by a hetero-atom, eg,^ N, 2 or by a substituted heteroatom, eg,—0~, 3 can be expressed in terms of the Hammett equation, 4 and substituent constants for these two groups have been proposed. The present paper deals with the question whether the above procedure can be reversed, ie, whether the Ham-mett equation can be used to predict the effect of substituents on the reactivity of the heteroatom, or of a side-chain attached to the heteroatom in a heterocyclic aromatic compound. Unfortunately, few experimental data on the reactivity of simple monosubstituted monocyclic heterocyclic com-pounds have been reported.