Pitx2 determines left-right asymmetry of internal organs in vertebrates
Pitx2 determines left-right asymmetry of internal organs in vertebrates
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DOI：
10.1038/29004
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发表时间：
1998-08-06
期刊：
影响因子：
64.8
通讯作者：
Belmonte, JCI
中科院分区：
文献类型：
--
作者：
Ryan, AK;Blumberg, B;Belmonte, JCI
内脏器官的惯用手在脊椎动物中是保守的，肛门受到Shh、Nodal和激活素等分子传递的不对称信号的调节。基因Pitx2在左侧板状中胚层中表达，随后在小鼠、鸡和非洲爪哇胚胎的左心和肠道中表达。Shh和Nodal的错误表达诱导了Pitx2的表达，而抑制激活素信号转导则阻止了它的表达。在鸡胚和非洲爪哇胚胎中，错误表达Pitx2改变了器官的相对位置和身体旋转的方向。在有偏侧缺陷的小鼠突变体中，Pitx2表达的变化是明显的。因此，在脊椎动物中，Pitx2似乎是调节左右不对称的关键下游转录靶点。
The handedness of visceral organs is conserved among vertebrates anal is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin. The gene Pitx2 is expressed in the left lateral plate mesoderm and, subsequently, In the left heart and gut of mouse, chick and Xenopus embryos. Misexpression of Shh and Nodal induces Pitx2 expression, whereas inhibition of activin signalling blocks it. Misexpression of Pitx2 alters the relative position of organs and the direction of body rotation In chick and Xenopus embryos. Changes in Pitx2 expression are evident in mouse mutants with laterality defects. Thus, Pitx2 seems to serve as a critical downstream transcription target that mediates left-right asymmetry in vertebrates.