Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals
Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals
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DOI：
10.1007/s10856-012-4844-7
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发表时间：
2013-01
期刊：
影响因子：
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通讯作者：
A. Ma;Nian Gong;J. Lu;Jin-lu Huang;B. Hao;Yang Guo;Jipin Zhong;Yuhong Xu;Jiang Chang;Yongxiang Wang
中科院分区：
文献类型：
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作者：
A. Ma;Nian Gong;J. Lu;Jin-lu Huang;B. Hao;Yang Guo;Jipin Zhong;Yuhong Xu;Jiang Chang;Yongxiang Wang
生物活性玻璃已被证明能促进骨骼再生和软组织愈合。在这项研究中，我们评估了生物活性玻璃对实验性胃溃疡的局部保护作用，并与奥美拉唑和水滑石进行了比较。45S5生物活性玻璃单次和多次灌胃对小鼠应激性溃疡和大鼠慢性溃疡均有剂量依赖性保护作用。连续7天多次灌胃生物活性玻璃可预防慢性溃疡复发50%。生物活性玻璃离子溶解使乙醇损伤的GES-1人胃粘膜上皮细胞在暴露48和72 h后显著增殖。生物活性玻璃在单次或多次灌胃后几乎不被吸收。本研究首次证实了生物活性玻璃对胃溃疡的保护作用，其疗效可与奥美拉唑媲美，优于水滑石。由于缺乏口服吸收，生物活性玻璃有可能用于治疗消化性溃疡，而不会产生全身毒性或副作用。
Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects.