Benzodiazepine withdrawal seizures and management.
Benzodiazepine withdrawal seizures and management.
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苯二氮卓戒断发作和治疗。
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Xiaohong Hu
中科院分区：
文献类型：
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作者：
Xiaohong Hu
自从1961年首次报道苯二氮卓类戒断发作以来，许多病例报道都随之而来。如果突然停药，短、中、长三种半衰期的苯二氮卓类药物都会发生戒断发作。戒断发作通常发生在长时间和高剂量服用这些药物的患者中。据报道，使用不到15天和治疗剂量的癫痫发作也有报道。几乎所有报告的戒断发作都是大发作。癫痫的严重程度从一次发作到昏迷和死亡不等。大剂量滥用者在医院环境下可以更快地减少苯二氮卓类药物的剂量，但在治疗性剂量使用者的门诊环境中必须更慢地进行。
Since the first report of benzodiazepine withdrawal seizure in 1961, many case reports have followed. Withdrawal seizures have occurred with short, medium, and long halflife benzodiazepine, if discontinued abruptly. Withdrawal seizures usually occur in patients who have been taking these medications for long periods of time and at high doses. Seizures have also been reported with less than 15 days of use and at therapeutic dosage. Almost all the withdrawal seizures reported were grand mal seizures. The severity of seizures range from a single episode to coma and death. Benzodiazepine dose tapering can be done faster in a hospital setting in high-dose abusers, but must be done more slowly in the outpatient setting in therapeutic dosage users.