DIRECT MEASUREMENT OF STATIC CHEST WALL COMPLIANCE IN ANIMAL AND HUMAN NEONATES
DIRECT MEASUREMENT OF STATIC CHEST WALL COMPLIANCE IN ANIMAL AND HUMAN NEONATES
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DOI：
10.1152/jappl.1988.65.3.1093
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发表时间：
1988-09-01
影响因子：
3.3
通讯作者：
BUREAU, MA
中科院分区：
文献类型：
--
作者：
DAVIS, GM;COATES, AL;BUREAU, MA
肺力学的测量已广泛发展为成人，这些技术已直接应用于新生儿和婴儿。然而，婴儿的顺应性胸壁经常倾向于胸壁变形，特别是当存在低动态肺顺应性（CL，dyn）时。我们描述了一种技术，直接测量静态胸壁顺应性（Cw，ST），最初在新生儿羔羊，随后应用于早产儿与胸壁变形。在常氧条件下，7只插管新生羔羊的平均CL，dyn为2.45。0.41 ml. cntdot. cmH2O-1. cntdot. kg ~（-1），而Cw，st为11.81 ± 0.01。0.25 ml. cntdot. cmH2O-1. cntdot. kg-1.这些值在通过紧身面罩呼吸或高碳酸血症诱导的呼吸急促的7只动物中没有显著变化。8名早产儿的平均CL，dyn为1.35 ±。0.36 ml. cntdot. cmH2O-1. cntdot. kg ~（-1），而平均Cw，st为3.16 . ±. 1.01 ml. cntdot. cmH2O-1. cntdot. kg-1.这项研究表明，在放松条件下，当进行静态顺应性测量时，胸壁比肺更顺应。因此，Cw，st的测量可以用于确定呼吸肌肉组织在稳定胸壁方面的贡献。
The measurement of pulmonary mechanics has been developed extensively for adults, and these techniques have been applied directly to neonates and infants. However, the compliant chest wall of the infant frequently predisposes to chest wall distortion, especially when there is a low dynamic lung compliance (CL,dyn). We describe a technique of directly measuring the static chest wall compliance (Cw,st), developed initially in the newborn lamb and subsequently applied to the premature neonate with chest wall distortion. The mean CL,dyn in seven intubated newborn lambs in normoxia was 2.45 .+-. 0.41 ml .cntdot. cmH2O-1 .cntdot. kg-1, whereas Cw,st was 11.81 .+-. 0.25 ml .cntdot. cmH2O-1 .cntdot. kg-1. These values did not change significantly in seven animals breathing through a tight-fitting face mask or with hypercapnia-induced tachypena. For the eight premature infants the mean CL,dyn was 1.35 .+-. 0.36 ml .cntdot. cmH2O-1 .cntdot. kg-1, whereas the mean Cw,st was 3.16 .+-. 1.01 ml .cntdot. cmH2O-1 .cntdot. kg-1. This study shows that, under relaxed conditions when measurements of static compliance are performed, the chest wall is more compliant than the lung. The measurement of Cw,st may thus be used to determine the contribution of the respiratory musculature in stabilizing the chest wall.