Prevalence of sarcopenic obesity and sarcopenic overweight in the general population: The lifelines cohort study
Prevalence of sarcopenic obesity and sarcopenic overweight in the general population: The lifelines cohort study
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DOI：
10.1016/j.clnu.2021.01.005
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发表时间：
2021-06-01
影响因子：
6.3
通讯作者：
Navis, Gerjan J.
中科院分区：
文献类型：
--
作者：
Wagenaar, Carlijn A.;Dekker, Louise H.;Navis, Gerjan J.
背景与目的：肌源性肥胖（SO）是指肌肉质量相对较低并伴有肥胖。Sarkanic肥胖症最初被认为是老年人群的健康风险，但最近被认为是一个科学和临床的优先事项，可能超出老年环境。肥胖通常是由超重，所以患病率和健康风险的肌肉减少症在那些超重（SOW）是感兴趣的预防目的。因此，本研究的目的是评估SO和SOW在一般population.Methods的患病率和决定因素：参与者（n = 119,494），年龄在18-90岁，包括从荷兰生命线队列研究。通过24小时尿肌酐排泄量评估肌肉质量，并按性别分层进行分析，肥胖定义为体重指数（BMI）≥ 30 kg/m2，超重≥ 25 kg/m2。结果：男性和女性SO患病率分别为0.9%和1.4%，SOW患病率分别为6.5%和6.0%。在肌肉减少症受试者中，45.5%的BMI>= 25 kg/m2，6.1%的BMI>= 30 kg/m2。总体而言，除40-59岁男性中的SOW外，所有年龄组中女性的SOW和SO患病率均较高。此外，年龄是SO和SOW的重要决定因素，50岁时患病率上升。在所有SO和SOW受试者中，分别有82.5%和80.4%的受试者年龄低于70岁。与无合并症的患者相比，合并症>3的患者中SO和SOW的比值比为2.71（95% CI：1.62-4.54）和1.33（95%CI：1.07-1.65），女性分别为1.14（95%CI：0.79-1.65）和1.28（95%CI：1.06-1.54），与其他因素无关。总体而言，发现SOW和SO和体力活动和大量营养素intake.Conclusion之间存在负相关：结果支持需要更多的认识SO超出老年医学领域，特别是在合并症的科目。SOW比SO更普遍，可能为一般人群提供预防策略的机会。(C)2021年，任作家。由爱思唯尔有限公司出版。这是一篇开放获取的文章，使用CC BY许可证（http：//creativecommons.org/licenses/by/4.0/）。
Background & aims: Sarcopenic obesity (SO) is defined by a relatively low muscle mass in combination with obesity. Sarcopenic obesity was first noted as a health risk in geriatric populations but has recently been recognized as a scientific and clinical priority that may extend beyond geriatric settings. Obesity is generally preceded by overweight, so the prevalence and health risks of sarcopenia in those with overweight (SOW) is of interest for preventive purposes. The aim of this study, therefore, was to assess the prevalence and determinants of SO and SOW in a general population.Methods: Participants (n = 119,494), aged 18-90 years were included from the Dutch Lifelines cohort study. Muscle mass was assessed by 24-h urine creatinine excretion and stratified for gender for analysis, and obesity was defined as a Body Mass Index (BMI) >= 30 kg/m(2) and overweight >= 25 kg/m(2). Multivariate logistic regression models were applied to assess the relevant determinants of SO and SOW.Results: Respectively for men and women the prevalence of SO was 0.9% and 1.4%, and prevalence of SOW 6.5% and 6.0%. In subjects with sarcopenia, BMI was >= 25 kg/m(2) in 45.5% and >= 30 kg/m(2) in 6.1%. Overall females had a higher prevalence of SOW and SO in all age groups except for SOW in males between ages 40-59. Also, age was a significant determinant of SO and SOW, with a rise in prevalence as of age 50. Of all subjects with SO and SOW, respectively 82.5% and 80.4% were below the age of 70. Compared to those with no morbidities, the odds ratio of SO and SOW among participants with >3 comorbidities was 2.71 (95% CI: 1.62-4.54) and 1.33 (95% CI: 1.07-1.65) among males and 1.14 (95% CI: 0.79-1.65) and 1.28 (95% CI: 1.06-1.54) among females, independent of other determinants. Overall, an inverse association was found between SOW and SO and physical activity and macronutrient intake.Conclusion: The results support the need for more awareness of SO beyond the field of geriatrics, in particular in subjects with comorbidities. SOW is more prevalent than SO and may provide opportunities for preventive strategies for the general population. (C) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).