Biophysical characterization of a large conductance anion channel in hypodermal membranes of the gastrointestinal nematode, Ascaris suum
Biophysical characterization of a large conductance anion channel in hypodermal membranes of the gastrointestinal nematode, Ascaris suum
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DOI：
10.1016/s1095-6433(03)00014-x
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发表时间：
2003-04-01
影响因子：
2.3
通讯作者：
Thompson, DP
中科院分区：
文献类型：
--
作者：
Blair, KL;Geary, TG;Thompson, DP
胃肠道线虫猪蛔虫面向肌肉和角质层的皮下膜的膜片钳记录揭示了高电导、电压敏感的 Ca2+ 依赖性 Cl- 通道。皮下通道在对称 160 mM NaCl 中的电导为 195 pS。通道的开放概率对电压高度敏感，当 Ca2+ 还原至
Patch-clamp recordings from muscle- and cuticle-facing hypodermal membranes of the gastrointestinal nematode Ascaris suum reveal a high-conductance, voltage-sensitive Ca2+-dependent Cl- channel. The hypodermal channel has a conductance of 195 pS in symmetrical 160 mM NaCl. The open probability of the channel is highly voltage-sensitive, and channel activity is not observed when Ca2+ is reduced to