INCREASED ENDOTHELIN-1 IN THE RABBIT MODEL OF MIDDLE CEREBRAL-ARTERY OCCLUSION
INCREASED ENDOTHELIN-1 IN THE RABBIT MODEL OF MIDDLE CEREBRAL-ARTERY OCCLUSION
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DOI：
10.1016/0304-3940(94)90115-5
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发表时间：
1994-06-06
影响因子：
2.5
通讯作者：
YANG, GY
中科院分区：
文献类型：
--
作者：
BIAN, LG;ZHANG, TX;YANG, GY
理论上，内皮素介导的血管收缩可能会加重缺血性神经元损伤。尽管研究人员在体外证明内皮素是由脑微血管内皮细胞、星形胶质细胞和神经元产生的，但内皮素是否在脑缺血过程中产生仍不清楚。因此，本研究的目的是测量大脑中动脉闭塞后脑组织和血浆中的内皮素1，并检查脑组织和血浆内皮素1水平之间的关系。阻断兔大脑中动脉2、4或24小时。通过RIA测定脑组织和血浆中内皮素-1的量。结果表明，局灶性脑缺血后，缺血脑组织和血浆中内皮素1浓度均显着升高（P < 0.01）。数据证实，脑组织和血浆中内皮素-1 的急剧显着增加与局灶性缺血事件相关。内皮素-1 在局灶性缺血后神经元细胞损伤中发挥作用的可能性值得进一步关注。
Endothelin-mediated vasoconstriction may theoretically aggravate ischemic neuronal damage. Although investigators have demonstrated that endothelins are produced by cerebral microvessel endothelial cells, astrocytes and neurons in vitro, whether endothelins are produced during cerebral ischemia is still unclear. The purpose of this study, therefore, was to measure endothelin-1 in brain tissue and plasma following middle cerebral artery occlusion and to examine the relationship between brain tissue and plasma endothelin-1 levels. The middle cerebral artery of rabbits was occluded for 2, 4 or 24 h. The amount of endothelin-1 in both brain tissue and plasma was determined by RIA. The results demonstrate that the concentrations of endothelin-1 in the ischemic brain tissue and plasma are both significantly increased after focal cerebral ischemia (P < 0.01). The data confirm that an acute and marked increase of endothelin-1 in brain tissue and plasma is associated with focal ischemic events. The possibility that endothelin-1 has a role in neuronal cell damage following focal ischemia warrants further attention.