The highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in the Drosophila visual system
The highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in the Drosophila visual system
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DOI：
10.1242/dev.02253
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发表时间：
2006-03-01
期刊：
影响因子：
4.6
通讯作者：
Tabata, T
中科院分区：
文献类型：
--
作者：
Umetsu, D;Murakami, S;Tabata, T
在果蝇视觉中心的发育过程中，光感受器细胞将其轴突(R轴突)延伸到板层神经节层，并通过传递诱导信号Hedgehog(HH)来触发突触伙伴(板层神经元)的增殖和分化。这种诱导机制有助于在R轴突和板层神经元之间建立有序的连接排列，称为视网膜定位图，因为它导致板层神经元定位在相应的R轴突附近。我们发现bHLH-PAS转录因子单一(Sim)是由HH在板层神经元中诱导的，是板层神经元与R轴突联系所必需的。在模拟突变型大脑中，板层神经元经历了分化的第一步，但无法与R轴突联系。结果，板层神经元从R轴突中分离出来。这些数据揭示了一种调节轴突和神经元胞体之间相互作用的新机制，该机制建立了精确的神经元网络。
During development of the Drosophila visual center, photoreceptor cells extend their axons (R axons) to the lamina ganglion layer, and trigger proliferation and differentiation of synaptic partners (lamina neurons) by delivering the inductive signal Hedgehog (Hh). This inductive mechanism helps to establish an orderly arrangement of connections between the R axons and lamina neurons, termed a retinotopic map because it results in positioning the lamina neurons in close vicinity to the corresponding R axons. We found that the bHLH-PAS transcription factor Single-minded (Sim) is induced by Hh in the lamina neurons and is required for the association of lamina neurons with R axons. In sim mutant brains, lamina neurons undergo the first step of differentiation but fail to associate with R axons. As a result, lamina neurons are set aside from R axons. The data reveal a novel mechanism for regulation of the interaction between axons and neuronal cell bodies that establishes precise neuronal networks.