Role of transcription factors in the age-dependent regulation of the androgen receptor gene in rat liver.
Role of transcription factors in the age-dependent regulation of the androgen receptor gene in rat liver.
复制标题
转录因子在大鼠肝脏雄激素受体基因年龄依赖性调节中的作用。
DOI：
10.1159/000109186
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Roy,AK
中科院分区：
文献类型：
--
作者：
Supakar,PC;Roy,AK
雄激素受体（AR）是一种配体激活的转录因子，参与介导男性生殖功能。 AR基因在年轻成年动物靶组织中的高表达通常伴随着在繁殖后阶段随年龄而下降。由于 AR 基因表达的伴随下降，雄性大鼠的肝脏在老年时雄激素敏感性下降约 50 至 100 倍。这种下降对应于与 AR 基因启动子结合的几种转录因子的核水平的变化。控制 AR 基因并经历年龄依赖性衰退的积极作用因子包括年龄依赖性转录因子 (ADF)、Sp1 和血清反应因子 (SRF)。核因子作为 AR 启动子的负调节因子，在肝雄激素敏感性随年龄增长而丧失的过程中经历了大约 10 倍的增加。此外，AP3 可能作为 AR 基因的调节因子，在老年时表现出显着增加。因此，许多正调节因子和负调节因子之间的协调相互作用似乎可以引导衰老过程中 AR 基因的下调。
Androgen receptor (AR) is a ligand-activated transcription factor involved in mediating male reproductive functions. The high expression of the AR gene in target tissues of young-adult animals is generally followed by an age-dependent decline during the postreproductive life. The liver of male rats shows about a 50- to 100-fold decline in androgen sensitivity during old age due to a concomitant decline of the AR gene expression. This decline corresponds to changes in the nuclear level of several transcription factors that bind to the AR gene promoter. The positively acting factors that control the AR gene and undergo an age-dependent decline include the age-dependent transcription factor (ADF), Sp1 and the serum response factor (SRF). Nuclear factor ĸwhich functions as a negative regulator of the AR promoter, undergoes about a 10-fold increase during the age-dependent loss of the hepatic androgen sensitivity. Additionally, AP3, which can potentially function as a regulator of the AR gene, shows a marked increase during old age. Thus, a coordinated interaction among a number of positive and negative regulators appears to guide the downregulation of the AR gene during aging.