Air Pollution and Preterm Birth in the U.S. State of Georgia (2002-2006): Associations with Concentrations of 11 Ambient Air Pollutants Estimated by Combining Community Multiscale Air Quality Model (CMAQ) Simulations with Stationary Monitor Measurements.
Air Pollution and Preterm Birth in the U.S. State of Georgia (2002-2006): Associations with Concentrations of 11 Ambient Air Pollutants Estimated by Combining Community Multiscale Air Quality Model (CMAQ) Simulations with Stationary Monitor Measurements.
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DOI：
10.1289/ehp.1409651
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发表时间：
2016-06
影响因子：
10.4
通讯作者：
Strickland MJ
中科院分区：
文献类型：
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作者：
Hao H;Chang HH;Holmes HA;Mulholland JA;Klein M;Darrow LA;Strickland MJ
以前的流行病学研究表明早产与环境空气污染之间存在联系。我们调查了11种环境空气污染物之间的关系，这些污染物是通过社区多尺度空气质量模型（CMAQ）模拟与固定监测器的测量结果相结合来估计的，与美国格鲁吉亚州早产（< 37周妊娠）的风险之间存在关联。从格鲁吉亚公共卫生部规划健康指标办公室获得2002年1月1日至2006年2月28日期间具有完整协变量信息和估计受孕日期的妊娠≥ 27周的单胎出生记录（n = 511，658例出生）。对11种环境空气污染物在12公里分辨率下的日污染物浓度进行了估算。我们使用logistic回归和县级固定效应来估计早产与前三个月和中三个月平均污染物浓度之间的关系。离散时间生存模型被用来估计晚期妊娠和总妊娠的关联。影响修改进行了调查，母亲的教育，种族，人口普查区贫困水平，县级城市化。观察到几种污染物与妊娠期特异性和总妊娠期相关性（p < 0.05）。所有与交通有关的污染物（一氧化碳、二氧化氮、PM2.5元素碳）都与早产有关[例如，妊娠早期、中期和晚期以及整个妊娠期间一氧化碳四分位距增加的优势比为1.005（95% CI：1.001，1.009）、1.007（95% CI：1.002，1.011）、1.010（95% CI：1.006，1.014）和1.011（95% CI：1.006，1.017）]。对于教育程度低的母亲和非裔美国人母亲来说，这种关联往往更高。几种环境空气污染物与早产有关;在所有暴露窗口中都观察到了相关性。Hao H，Chang HH，Holmes HA，Mulholland JA，Klein M，Darrow LA，Strickland MJ. 2016.美国格鲁吉亚州的空气污染和早产（2002-2006年）：与通过社区多尺度空气质量模型（CMAQ）模拟与固定监测器测量相结合估计的11种环境空气污染物浓度的关联。环境健康展望124：875-880; http：dx.doi.org/10.1289/ehp.1409651
Previous epidemiologic studies suggest associations between preterm birth and ambient air pollution. We investigated associations between 11 ambient air pollutants, estimated by combining Community Multiscale Air Quality model (CMAQ) simulations with measurements from stationary monitors, and risk of preterm birth (< 37 weeks of gestation) in the U.S. state of Georgia. Birth records for singleton births ≥ 27 weeks of gestation with complete covariate information and estimated dates of conception between 1 January 2002 and 28 February 2006 were obtained from the Office of Health Indicators for Planning, Georgia Department of Public Health (n = 511,658 births). Daily pollutant concentrations at 12-km resolution were estimated for 11 ambient air pollutants. We used logistic regression with county-level fixed effects to estimate associations between preterm birth and average pollutant concentrations during the first and second trimester. Discrete-time survival models were used to estimate third-trimester and total pregnancy associations. Effect modification was investigated by maternal education, race, census tract poverty level, and county-level urbanicity. Trimester-specific and total pregnancy associations (p < 0.05) were observed for several pollutants. All the traffic-related pollutants (carbon monoxide, nitrogen dioxide, PM2.5 elemental carbon) were associated with preterm birth [e.g., odds ratios for interquartile range increases in carbon monoxide during the first, second, and third trimesters and total pregnancy were 1.005 (95% CI: 1.001, 1.009), 1.007 (95% CI: 1.002, 1.011), 1.010 (95% CI: 1.006, 1.014), and 1.011 (95% CI: 1.006, 1.017)]. Associations tended to be higher for mothers with low educational attainment and African American mothers. Several ambient air pollutants were associated with preterm birth; associations were observed in all exposure windows. Hao H, Chang HH, Holmes HA, Mulholland JA, Klein M, Darrow LA, Strickland MJ. 2016. Air pollution and preterm birth in the U.S. state of Georgia (2002–2006): associations with concentrations of 11 ambient air pollutants estimated by combining Community Multiscale Air Quality Model (CMAQ) simulations with stationary monitor measurements. Environ Health Perspect 124:875–880; http://dx.doi.org/10.1289/ehp.1409651