Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits
Facilitation of calmodulin-mediated odor adaptation by cAMP-gated channel subunits
复制标题
DOI：
10.1126/science.1063415
复制
发表时间：
2001-12-07
期刊：
影响因子：
56.9
通讯作者：
Frings, S
中科院分区：
文献类型：
--
作者：
Bradley, J;Reuter, D;Frings, S
钙(Ca(2+))通过钙离子通道的内流在多种神经元信号转导过程中起着关键作用，而钙离子本身对这种内流的负反馈控制对信号的调节也同样重要。Ca(2+)通过钙调素(CaM)对环核苷酸门控(CNG)通道的负性调制是嗅觉感受器神经元对气味适应的基础。我们表明，这种反馈需要天然嗅觉通道的两个额外的亚基，CNGA4和CNGB1b，尽管CaM结合和调制的机制存在于主要的亚基CNGA2中。这为天然嗅觉通道中存在三个不同的亚基提供了理论基础，并强调了离子通道的分子组成与其所伴随的生理功能之间的微妙联系。
Calcium (Ca(2+)) influx through Ca(2+)-permeable ion channels plays a pivotal role in a variety of neuronal signaling processes, and negative-feed back control of this influx by Ca(2+) itself is often equally important for modulation of such signaling. Negative modulation by Ca(2+) through calmodulin (CaM) on cyclic nucleotide-gated (CNG) channels underlies the adaptation of olfactory receptor neurons to odorants. We show that this feedback requires two additional subunits of the native olfactory channel, CNGA4 and CNGB1b, even though the machinery for CaM binding and modulation is present in the principal subunit CNGA2. This provides a rationale for the presence of three distinct subunits in the native olfactory channel and underscores the subtle link between the molecular make-up of an ion channel and the physiological function it subserves.