IMMUNOGLOBULIN-MEDIATED PREVENTION OF AUTOIMMUNE DIABETES IN THE NONOBESE DIABETIC (NOD) MOUSE
IMMUNOGLOBULIN-MEDIATED PREVENTION OF AUTOIMMUNE DIABETES IN THE NONOBESE DIABETIC (NOD) MOUSE
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DOI：
10.1111/j.1365-3083.1991.tb01567.x
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发表时间：
1991-10-01
影响因子：
3.7
通讯作者：
HOLMBERG, D
中科院分区：
文献类型：
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作者：
FORSGREN, S;ANDERSSON, A;HOLMBERG, D
我们研究了 NOD 小鼠自发 T 细胞介导的 I 型糖尿病的发展是否受到 B 细胞和免疫球蛋白 (Ig) 的影响。在生命的前 4 周内，重复施用兔抗小鼠 IgM (RaIgM) 会抑制 B 细胞发育，而对照组则接受多克隆兔 Ig (NRIg)。经过这两种治疗后，观察到糖尿病的发病率以及胰岛素炎的发生率都有所下降。然而，与用 NRIg 治疗的小鼠相比，用 RaIgM 治疗的小鼠对胰岛素炎的作用更为明显。此外，虽然 NRIg 的最佳效果是在出生时注射一次后获得的，但 RaIgM 对胰岛素炎发展的额外作用只有在生命的前 4 周持续治疗后才能观察到。综上所述，这些数据表明 Ig/B 细胞在 NOD 小鼠自身免疫发展中可能发挥作用。持续抑制新生儿 B 细胞发育后观察到的额外效应表明，该群体可能对 NOD 小鼠中自身攻击性淋巴细胞库的建立做出了重大贡献。
We investigated whether the development of spontaneous T-cell-mediated type I diabetes in NOD mice is influenced by B cells and immunoglobulin (Ig). During the first 4 weeks of life, B-cell development was suppressed by repeated administration of rabbit anti-mouse IgM (RaIgM), while controls received polyclonal rabbit Ig (NRIg). A reduction in the incidence of diabetes, as well as in development of insulitis, was observed after either of these treatments. However, the effect on insulitis was more pronounced in mice treated with RaIgM compared with those treated with NRIg. Furthermore, while the optimal effect of NRIg was obtained after a single injection at birth, the additional effect of RaIgM on development of insulitis was observed only after continued treatment for the first 4 weeks of life. Taken together these data suggest a possible role of Ig/B cells in the development of autoimmunity in the NOD mouse. The additional effect observed after continued suppression of the neonatal B-cell development suggests that this population may contribute significantly to the establishment of an auto-aggressive lymphocyte repertoire in the NOD mouse.