Are deficits in the equilibrium system relevant to the clinical investigation of solvent-induced neurotoxicity?
Are deficits in the equilibrium system relevant to the clinical investigation of solvent-induced neurotoxicity?
复制标题
平衡系统的缺陷与溶剂引起的神经毒性的临床研究相关吗？
DOI：
10.5271/sjweh.200
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
A. Sköldestig
中科院分区：
文献类型：
--
作者：
M. Niklasson;C. Möller;L. Odkvist;K. Ekberg;U. Flodin;N. Dige;A. Sköldestig
目标
溶剂引起的慢性中毒性脑病的诊断通常基于接触溶剂的病史、症状和心理测试缺陷。先前已经证明，长期接触溶剂的工人会扰乱平衡系统。本研究分析了这些紊乱与慢性中毒性脑病诊断之间的相关性。
材料和方法
对因怀疑患有该综合征而连续入院的 60 名男性进行了调查，并将其分为 3 组：溶剂诱发的慢性中毒性脑病、初期慢性中毒性脑病和非慢性中毒性脑病。他们都使用耳神经学测试组进行了检查，包括眼跳分析、平滑追踪、前庭眼反射的视觉抑制和动态姿势描记术。
结果
与健康受试者相比，一些受试者，甚至在非慢性中毒性脑病组中，也表现出视觉抑制能力降低、眼跳潜伏期延长和病理姿势描记结果。一些耳神经学测试与暴露时间以及代表记忆和感知技能的心理测试结果相关。然而，耳神经学检查结果与慢性中毒性脑病的诊断之间不存在显着的群体相关性。
结论
迄今为止，在慢性中毒性脑病的诊断中尚未考虑耳神经学检查所揭示的紊乱。我们的结果表明，耳神经学测试电池组增加了有关脑干-小脑复合体内病变的有价值的信息，而心理测量学调查并未揭示这些信息。
OBJECTIVES
The diagnosis of solvent-induced chronic toxic encephalopathy is commonly based on case histories of exposure to solvents, symptoms, and deficits on psychometric tests. It has previously been demonstrated that long-term solvent-exposed workers have disturbances of the equilibrium system. The correlation between these disturbances and the diagnosis of chronic toxic encephalopathy has been analyzed in the present study.
MATERIAL AND METHODS
Sixty men, consecutively admitted due to the suspicion of this syndrome, were investigated and classified into 3 groups--solvent-induced chronic toxic encephalopathy, incipient chronic toxic encephalopathy and nonchronic toxic encephalopathy. They were all examined using an otoneurological test battery, including analysis of saccades, smooth pursuit, visual suppression of the vestibular ocular reflex, and dynamic posturography.
RESULTS
Compared with healthy referents several of the subjects, even in the nonchronic toxic encephalopathy group, showed a reduced visual suppression ability, a prolonged latency of saccades, and pathological posturographic results. Some otoneurological tests correlated with the duration of exposure and the results of psychometric tests representing memory and perceptual skills. Nevertheless, there was no significant group correlation between the otoneurological findings and the diagnosis of chronic toxic encephalopathy.
CONCLUSION
Disturbances revealed by an otoneurological investigation have so far not been considered in the diagnosis of chronic toxic encephalopathy. Our results indicate that an otoneurological test battery adds worthwhile information about lesions within the brainstem-cerebellar complex not revealed by a psychometric investigation.