A simple molecular mathematical model of mammalian hibernation
A simple molecular mathematical model of mammalian hibernation
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DOI：
10.1016/j.jtbi.2007.03.005
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发表时间：
2007-07-21
影响因子：
2
通讯作者：
Andrews, Matthew T.
中科院分区：
文献类型：
--
作者：
Hampton, Marshall;Andrews, Matthew T.
提出了冬眠哺乳动物体温动力学的一个简单模型。我们的模型与实验数据吻合较好，显示了周期性间歇唤醒（）对低温休眠发作的中断。在本文中，我们提出了参与启动，调节和维持休眠状态的分子的数学模型。该模型可用于描述调节分子、信号转导器、下游靶酶、结构蛋白或代谢物的作用。由于许多生化机制是未知的，这是一个初步的，很大程度上是现象学的模型，我们希望能激发进一步的研究。(C) 2007 Elsevier Ltd.版权所有。
A simple model of the dynamics of the body temperature of a hibernating mammal is presented. Our model provides a good match to experimental data, showing the interruption of low-temperature torpor bouts with periodic interbout arousals (IBAs). In this paper we present a mathematical model of the molecules that participate in the initiation, regulation, and maintenance of the hibernating state. This model can be used to describe the role of regulatory molecules, signal transducers, downstream target enzymes, structural proteins, or metabolites. Because many of the biochemical mechanisms are unknown, this is a preliminary and largely phenomenological model that we hope will inspire further investigation. (C) 2007 Elsevier Ltd. All rights reserved.