Plasma nicotine concentrations from repeated doses of nasal nicotine solution.
Plasma nicotine concentrations from repeated doses of nasal nicotine solution.
复制标题
重复剂量鼻腔尼古丁溶液的血浆尼古丁浓度。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
C. Feyerabend
中科院分区：
文献类型：
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作者：
R. West;M. Jarvis;M. Russell;C. Feyerabend
总结
Summary
A nasal nicotine solution (NNS) has been proposed as a potential cessation aid for cigarette smokers [1], the principle being similar to that underlying use of nicotine chewing gum, i.e. nicotine replacement following cessation to ease withdrawal symptoms. We conducted a study to determine the plasma nicotine concentrations resulting from eight, hourly administrations of 2 mg NNS. The peak plasma nicotine concentrations rose to an average of 16.3 ng/ml, which is higher than is normally obtained from 2 mg nicotine chewing gum. There was considerable variability in levels obtained from the NNS, with one subject obtaining levels similar to those found in heavy cigarette smokers. The initial doses produced noticeable light headedness in four of the five subjects. Nasal nicotine solution could provide more effective nicotine replacement than nicotine gum.