Immunoperoxidase study of uncommon parathyroid tumors Report of two cases of nonfunctioning parathyroid carcinoma and one intrathyroid parathyroid tumor‐producing amyloid
Immunoperoxidase study of uncommon parathyroid tumors Report of two cases of nonfunctioning parathyroid carcinoma and one intrathyroid parathyroid tumor‐producing amyloid
复制标题
罕见甲状旁腺肿瘤的免疫过氧化物酶研究 两例无功能甲状旁腺癌和一例甲状腺内甲状旁腺肿瘤产生淀粉样蛋白的报告
DOI：
10.1097/00000478-198309000-00004
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
R. C. Hickey
中科院分区：
文献类型：
--
作者：
N. Ordóñez;M. Ibanez;N. Samaan;R. C. Hickey
甲状旁腺无功能癌很少见，很难诊断。它们经常与甲状腺肿瘤或其他部位的转移相混淆。我们报告两例无功能性甲状旁腺癌，其中一例最初被诊断为甲状腺滤泡性癌。肿瘤细胞中甲状旁腺激素的免疫组织化学显示证实了这些肿瘤的甲状旁腺起源。1例原发性甲状旁腺功能亢进症患者的甲状腺内甲状旁腺肿瘤，伴有大量间质淀粉样蛋白，类似于甲状腺髓样癌。肿瘤细胞甲状旁腺激素免疫反应阳性，降钙素染色阴性，以及肿瘤切除后患者血清钙水平恢复正常，证实了该肿瘤的甲状旁腺性质。免疫组织化学研究证明对这些罕见的甲状旁腺肿瘤的诊断非常有帮助。
Nonfunctioning carcinomas of the parathyroid gland are rare and difficult to diagnose. They are often confused with thyroid tumors or with metastasis from other sites. We report two cases of nonfunctioning parathyroid carcinomas; one was originally diagnosed as follicular carcinoma of the thyroid gland. The immuno-histochemical demonstration of parathormone in the tumor cells established the parathyroid origin of these neoplasms. An intrathyroid parathyroid tumor, associated with large amounts of interstitial amyloid, mimicking medullary carcinoma of the thyroid, in a patient with primary hyperparathyroidism is also reported. Positive immunoreaction in the tumor cells for parathormone, negative staining for calcitonin, and the return of patients' serum calcium levels to normal after tumor resection, confirmed the parathyroid nature of this neoplasm. Immunohistochemistry studies proved to be extremely helpful in establishing the diagnoses of these unusual parathyroid tumors.